Prominent Changes in Cerebro-Cerebellar Functional Connectivity During Continuous Cognitive Processing.
Prominent Changes in Cerebro-Cerebellar Functional Connectivity During Continuous Cognitive Processing.
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DOI：
10.3389/fncel.2018.00331
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发表时间：
2018
影响因子：
5.3
通讯作者：
Wheeler-Kingshott CAMG
中科院分区：
文献类型：
--
作者：
Castellazzi G;Bruno SD;Toosy AT;Casiraghi L;Palesi F;Savini G;D'Angelo E;Wheeler-Kingshott CAMG
虽然认知任务期间特定大脑区域的任务依赖性反应已得到很好的证实，但人们对与连续认知处理相关的静息状态网络（RSN）中发生的变化知之甚少。特别是，连接小脑后部和关联皮质的脑小脑环的功能参与仍不清楚。在这项研究中，22 名健康志愿者接受了多期功能磁共振成像 (fMRI) 方案，该方案由四次连续 8 分钟静息态 fMRI (rs-fMRI) 扫描组成。第一次对照扫描后，参与者在第二次 rs-fMRI 扫描的整个过程中聆听讲述的故事；听完故事后，又进行了两次 rs-fMRI 扫描。故事情节经过专门设计，旨在刺激已知涉及大脑-小脑环路的特定认知过程。几乎所有已识别的 15 个 RSN 在故事发生期间和故事发生后几分钟内都显示出功能连接 (FC) 的变化。 FC变化主要发生在额叶、前额叶皮质和小脑后部，特别是小腿I-II和VI小叶。 FC变化发生在属于不同RSN的小脑簇中，包括小脑网络（CBLN）、感觉网络（外侧视觉网络，LVN；内侧视觉网络，MVN）和认知网络（默认模式网络，DMN；执行控制网络，ECN；左右腹侧注意网络，RVAN和LVAN；显着网络，SN；语言网络，LN；和工作记忆网络，WMN）。有趣的是，对 FC 变化的 k 均值分析揭示了 FCN、ECN 和 WMN 的聚类（它们都与工作记忆功能有关）、CBLN、DMN 和 SN（在注意切换中发挥关键作用）以及 RSN（与视觉意象有关）。这些结果表明，小脑深深地陷入结构良好的网络簇中，这些网络簇反映了听觉刺激期间和结束后认知处理的多个方面。
While task-dependent responses of specific brain areas during cognitive tasks are well established, much less is known about the changes occurring in resting state networks (RSNs) in relation to continuous cognitive processing. In particular, the functional involvement of cerebro-cerebellar loops connecting the posterior cerebellum to associative cortices, remains unclear. In this study, 22 healthy volunteers underwent a multi-session functional magnetic resonance imaging (fMRI) protocol composed of four consecutive 8-min resting state fMRI (rs-fMRI) scans. After a first control scan, participants listened to a narrated story for the entire duration of the second rs-fMRI scan; two further rs-fMRI scans followed the end of story listening. The story plot was purposely designed to stimulate specific cognitive processes that are known to involve the cerebro-cerebellar loops. Almost all of the identified 15 RSNs showed changes in functional connectivity (FC) during and for several minutes after the story. The FC changes mainly occurred in the frontal and prefrontal cortices and in the posterior cerebellum, especially in Crus I-II and lobule VI. The FC changes occurred in cerebellar clusters belonging to different RSNs, including the cerebellar network (CBLN), sensory networks (lateral visual network, LVN; medial visual network, MVN) and cognitive networks (default mode network, DMN; executive control network, ECN; right and left ventral attention networks, RVAN and LVAN; salience network, SN; language network, LN; and working memory network, WMN). Interestingly, a k-means analysis of FC changes revealed clustering of FCN, ECN, and WMN, which are all involved in working memory functions, CBLN, DMN, and SN, which play a key-role in attention switching, and RSNs involved in visual imagery. These results show that the cerebellum is deeply entrained in well-structured network clusters, which reflect multiple aspects of cognitive processing, during and beyond the conclusion of auditory stimulation.
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影响因子：
5.7
作者：
Ferrari, Chiara;Oldrati, Viola;Cattaneo, Zaira
通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
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通讯作者：
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影响因子：
5.7
作者：
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