Bacterial Infections and Cancer: Exploring This Association And Its Implications for Cancer Patients.
Bacterial Infections and Cancer: Exploring This Association And Its Implications for Cancer Patients.
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DOI：
10.3390/ijms24043110
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发表时间：
2023-02-04
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
由于细菌的普遍存在，细菌感染在人类疾病的病因学中很常见。这些感染会促进易感宿主的牙周病、细菌性肺炎、伤寒、急性胃肠炎和腹泻的发展。这些疾病可以在某些宿主中使用抗生素/抗微生物疗法来解决。然而，其他宿主可能无法消除细菌，使它们能够持续很长时间，并随着时间的推移显著增加携带者患癌症的风险。事实上，传染性病原体是可改变的癌症风险因素，通过这一全面的综述，我们强调了细菌感染和几种癌症类型的发展之间的复杂关系。在这篇综述中，对PubMed、Embase和Web of Science数据库进行了搜索，涵盖了2022年的全部内容。根据我们的调查，我们发现了几个关键的关联，其中一些是致病的：牙龈卟啉单胞菌和核梭杆菌与牙周病有关，沙门氏菌、产气荚膜梭菌、大肠杆菌、弯曲杆菌和志贺氏菌与胃肠炎有关。幽门螺杆菌感染与胃癌的病因有关，而持续的衣原体感染是宫颈癌的危险因素，尤其是在合并人乳头状瘤病毒(HPV)感染的患者中。伤寒沙门氏菌感染与胆囊癌有关，肺炎衣原体感染与肺癌等有关。这些知识有助于确定细菌用来逃避抗生素/抗微生物治疗的适应策略。文章还阐明了抗生素在癌症治疗中的作用，使用抗生素的后果，以及限制抗生素耐药性的策略。最后，简要讨论了细菌在癌症发展和癌症治疗中的双重作用，因为这一领域可能有助于促进以微生物为基础的新疗法的开发，以确保改善结果。
Bacterial infections are common in the etiology of human diseases owing to the ubiquity of bacteria. Such infections promote the development of periodontal disease, bacterial pneumonia, typhoid, acute gastroenteritis, and diarrhea in susceptible hosts. These diseases may be resolved using antibiotics/antimicrobial therapy in some hosts. However, other hosts may be unable to eliminate the bacteria, allowing them to persist for long durations and significantly increasing the carrier's risk of developing cancer over time. Indeed, infectious pathogens are modifiable cancer risk factors, and through this comprehensive review, we highlight the complex relationship between bacterial infections and the development of several cancer types. For this review, searches were performed on the PubMed, Embase, and Web of Science databases encompassing the entirety of 2022. Based on our investigation, we found several critical associations, of which some are causative: Porphyromonas gingivalis and Fusobacterium nucleatum are associated with periodontal disease, Salmonella spp., Clostridium perfringens, Escherichia coli, Campylobacter spp., and Shigella are associated with gastroenteritis. Helicobacter pylori infection is implicated in the etiology of gastric cancer, and persistent Chlamydia infections present a risk factor for the development of cervical carcinoma, especially in patients with the human papillomavirus (HPV) coinfection. Salmonella typhi infections are linked with gallbladder cancer, and Chlamydia pneumoniae infection is implicated in lung cancer, etc. This knowledge helps identify the adaptation strategies used by bacteria to evade antibiotic/antimicrobial therapy. The article also sheds light on the role of antibiotics in cancer treatment, the consequences of their use, and strategies for limiting antibiotic resistance. Finally, the dual role of bacteria in cancer development as well as in cancer therapy is briefly discussed, as this is an area that may help to facilitate the development of novel microbe-based therapeutics as a means of securing improved outcomes.
影响因子：
5.7
作者：
Kim IJ;Blanke SR
通讯作者：
Blanke SR
影响因子：
3.7
作者：
Gonzalez-Escobedo G;La Perle KM;Gunn JS
通讯作者：
Gunn JS