Histopathological analysis of Salmonella chronic carriage in the mouse hepatopancreatobiliary system.
Histopathological analysis of Salmonella chronic carriage in the mouse hepatopancreatobiliary system.
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DOI：
10.1371/journal.pone.0084058
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gunn JS
中科院分区：
文献类型：
--
作者：
Gonzalez-Escobedo G;La Perle KM;Gunn JS
伤寒沙门氏菌无症状慢性携带者对流行地区伤寒的诊断和预防提出了挑战。这些携带者被认为是疾病进一步传播的蓄水池。已经证实，胆结石上生物膜的形成和小鼠胆囊上皮细胞内的持续存在是胆囊壁携带的主要机制。此外，胆结石和慢性携带者都与慢性炎症和胆囊癌的发展有关。然而，伤寒携带与肝胰胆系统癌前病变和/或恶性病变的发生以及慢性携带过程中宿主与病原体的相互作用的致病关系尚不清楚。在这项研究中，我们监测了慢性携带者感染后1年的组织病理学特征。无论是否有胆结石，感染的小鼠都会出现从轻度到重度的慢性胆囊炎和肝炎。胆结石小鼠(未感染或感染)的胆管上皮细胞增生更为常见。然而，癌前病变、不典型增生和胰腺化生分别与慢性沙门氏菌携带者有关。这项研究对沙门氏菌慢性感染和炎症在可能导致肿瘤发生的胆囊癌前病变和胰腺癌前病变的发展中所起的作用有一定的意义。
Salmonella Typhi asymptomatic chronic carriage represents a challenge for the diagnosis and prevention of typhoid fever in endemic areas. Such carriers are thought to be reservoirs for further spread of the disease. Gallbladder carriage has been demonstrated to be mediated by biofilm formation on gallstones and by intracellular persistence in the gallbladder epithelium of mice. In addition, both gallstones and chronic carriage have been associated with chronic inflammation and the development of gallbladder carcinoma. However, the pathogenic relationship between typhoid carriage and the development of pre-malignant and/or malignant lesions in the hepatopancreatobiliary system as well as the host-pathogen interactions occurring during chronic carriage remains unclear. In this study, we monitored the histopathological features of chronic carriage up to 1 year post-infection. Chronic cholecystitis and hepatitis ranging from mild to severe were present in infected mice regardless of the presence of gallstones. Biliary epithelial hyperplasia was observed more commonly in the gallbladder of mice with gallstones (uninfected or infected). However, pre-malignant lesions, atypical hyperplasia and metaplasia of the gallbladder and exocrine pancreas, respectively, were only associated with chronic Salmonella carriage. This study has implications regarding the role of Salmonella chronic infection and inflammation in the development of pre-malignant lesions in the epithelium of the gallbladder and pancreas that could lead to oncogenesis.
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DOI：
10.1111/j.1445-2197.1995.tb00588.x
发表时间：
1995-12-01
期刊：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY
影响因子：
--
作者：
Gosbell, I;Jones, PD;Yeo, B
通讯作者：
Yeo, B
影响因子：
3.1
作者：
Gonzalez-Escobedo, Geoffrey;Gunn, John S.
通讯作者：
Gunn, John S.
影响因子：
5.8
作者：
Jepson, MA;Clark, MA
通讯作者：
Clark, MA
影响因子：
3
作者：
CSENDES, A;FERNANDEZ, M;URIBE, P
通讯作者：
URIBE, P
影响因子：
9.8
作者：
CHANG, HR;DULLOO, AG;PECHERE, JC
通讯作者：
PECHERE, JC