Structure and composition of pulmonary arteries, capillaries, and veins.
Structure and composition of pulmonary arteries, capillaries, and veins.
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DOI：
10.1002/cphy.c100081
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发表时间：
2012-01
影响因子：
5.8
通讯作者：
Townsley MI
中科院分区：
文献类型：
--
作者：
Townsley MI
肺脉管系统由三个连续连接的解剖室组成：动脉树、广泛的毛细血管床和静脉树。虽然通常这种脉管系统是薄壁的，但结构仍然是复杂的。应考虑内皮细胞和平滑肌细胞以外的细胞以及细胞外基质细胞对结构（因此可能对功能）的贡献。这篇综述是多方面的，包括以下方面的信息：1)肺血管的分类，2)肺血管树的分支几何，3)基于血管壁形态测量的结构定量视图，4)神经，各种间质细胞，基质蛋白，横纹肌细胞与血管壁平滑肌和内皮的关系，5)细胞群内和血管室之间的异质性，6)同型和异型细胞-细胞连接复合物，7)肺血管与气道血管的关系。这些问题的肺血管结构进行比较，当数据可用时，跨物种从人类到小鼠和鼩鼱。利用血管铸型、光学和电子显微镜的研究数据，以及从这些数据开发的模型，进行了讨论。最后，强调需要严格的定量方法来研究肺血管结构。
The pulmonary vasculature is comprised of three anatomic compartments connected in series: the arterial tree, an extensive capillary bed, and the venular tree. Although in general this vasculature is thin-walled, structure is nonetheless complex. Contributions to structure (and thus potentially to function) from cells other than endothelial and smooth muscle cells as well as those from the extracellular matrix should be considered. This review is multifaceted, bringing together information regarding 1) classification of pulmonary vessels, 2) branching geometry in the pulmonary vascular tree, 3) a quantitative view of structure based on morphometry of the vascular wall, 4) the relationship of nerves, a variety of interstitial cells, matrix proteins, and striated myocytes to smooth muscle and endothelium in the vascular wall, 5) heterogeneity within cell populations and between vascular compartments, 6) homo- and heterotypic cell-cell junctional complexes, and 7) the relation of the pulmonary vasculature to that of airways. These issues for pulmonary vascular structure are compared, when data is available, across species from human to mouse and shrew. Data from studies utilizing vascular casting, light and electron microscopy, as well as models developed from those data, are discussed. Finally, the need for rigorous quantitative approaches to study of vascular structure in lung is highlighted.
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DOI：
10.1152/ajplung.2000.278.5.l981
发表时间：
2000-05-01
影响因子：
4.9
作者：
Aguirre, JI;Morrell, NW;Wilkins, MR
通讯作者：
Wilkins, MR
影响因子：
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影响因子：
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DOI：
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发表时间：
2004-07-23
影响因子：
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作者：
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通讯作者：
Shibahara, S
影响因子：
37.8
作者：
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