Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range
Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range
复制标题
量化人类昼夜节律起搏器对感光范围内短暂、长时间和重复光刺激的反应
DOI：
10.1177/074873049901400609
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发表时间：
1999
影响因子：
3.5
通讯作者：
M. Jewett
中科院分区：
文献类型：
--
作者：
R. Kronauer;Daniel B. Forger;M. Jewett
作者之前的模型已经能够准确描述长时间（5小时）强光（>4000勒克斯）刺激对人类昼夜节律起搏器的相位和幅度的影响，但它们不足以代表人类对强光短暂脉冲和中等强度光的令人惊讶的敏感性。因此，作者设计了一种新模型，其中动态刺激处理器（进程 L）作为自维持极限循环振荡器（进程 P）介入光刺激和昼夜节律起搏器的传统表示之间。包含过程 L 和过程 P 的整体模型旨在允许预测任何时间模式（延长和短暂的光事件）以及明视范围内的任何光强度的光刺激的相移。过程 L 模型中出现了两个时间常数：达到其全部效果所需的亮光脉冲的特征持续时间（5-10 分钟）和可以容忍的特征无刺激（暗）间隔，而不会在相移中造成过多的损失（30-80 分钟）。降低光强度的效果被纳入过程 L 中，作为完全实现光脉冲所需的时间的延长（时间和强度之间的幂律关系）。这个新模型产生了许多新的可检验的假设，包括令人惊讶的预测，即由 8 小时黑暗和 16 小时仅 3.5 勒克斯组成的 24 小时循环将能够吸引大部分成年人口 (45%)。需要有关人类昼夜节律系统对较低光强度和较短刺激的反应的实验数据，以便进一步完善和验证此处提出的模型。
The authors' previous models have been able to describe accurately the effects of extended (5 h) bright-light (>4000 lux) stimuli on the phase and amplitude of the human circadian pacemaker, but they are not sufficient to represent the surprising human sensitivity to both brief pulses of bright light and light of more moderate intensities. Therefore, the authors have devised a new model in which a dynamic stimulus processor (Process L) intervenes between the light stimuli and the traditional representation of the circadian pacemaker as a self-sustaining limit-cycle oscillator (Process P). The overall model incorporating Process L and Process P is intended to allow the prediction of phase shifts to photic stimuli of any temporal pattern (extended and brief light episodes) and any light intensity in the photopic range. Two time constants emerge in the Process Lmodel: the characteristic duration for necessary bright-light pulses to achieve their full effect (5-10 min) and the characteristic stimulus-free (dark) interval that can be tolerated without incurring an excessive penalty in phase shifting (30-80 min). The effect of reducing light intensity is incorporated in Process L as an extension of the time necessary for the light pulse to be fully realized (a power-law relation between time and intensity). This new model generates a number of new testable hypotheses, including the surprising prediction that 24-h cycles consisting of8hof darkness and 16 h of only 3.5 lux would be capable of entraining a large fraction of the adult population (45%). Experimental data on the response of the human circadian system to lower light intensities and briefer stimuli are needed to allow for further refinement and validation of the model proposed here.
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影响因子：
5.5
作者：
NELSON, DE;TAKAHASHI, JS
通讯作者：
TAKAHASHI, JS
影响因子：
56.9
作者：
Czeisler, CA;Duffy, JF;Kronauer, RE
通讯作者：
Kronauer, RE
影响因子：
2
作者：
Jewett, ME;Kronauer, RE
通讯作者：
Kronauer, RE
DOI：
10.1073/pnas.84.6.1694
发表时间：
1987-03-01
影响因子：
11.1
作者：
SCHWARTZ, WJ;GROSS, RA;MORTON, MT
通讯作者：
MORTON, MT