Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults.
Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults.
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DOI：
10.1186/s12933-021-01377-5
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发表时间：
2021-09-09
影响因子：
9.3
通讯作者：
Kang HT
中科院分区：
文献类型：
--
作者：
Kim J;Shin SJ;Kim YS;Kang HT
胰岛素抵抗与糖尿病和心血管疾病（如心肌梗死）的发病率有关。甘油三酯（TG）与高密度脂蛋白胆固醇（HDL-C）的比值（TG/HDL-C比值）与胰岛素抵抗呈正相关。本研究旨在探讨韩国成年人TG/HDL-C比值与糖尿病发病率之间的关系。这项回顾性研究使用了国民健康保险服务-国民健康筛查队列的数据。TG/HDL-C比率根据性别分为T1、T2和T3组。我们使用多变量Cox比例风险回归分析估计糖尿病的风险比（hr）和95%置信区间（CIs）。共有80,693名年龄在40至79岁之间的受试者入组。中位随访期为5.9年。估计T1、T2和T3组的糖尿病累积发病率男性分别为5.94%、8.23%和13.50%，女性分别为4.12%、4.72%和6.85%。与T1相比，T2组和T3组新发糖尿病的完全调整hr （95% ci）男性分别为1.17（1.06-1.30）和1.47(1.34-1.62)，女性分别为1.20（1.02-1.42）和1.52（1.30-1.78）。TG/HDL-C比值升高与两性新发糖尿病的高风险显著相关。在线版本包含补充材料，可在10.1186/s12933-021-01377-5获得。
Insulin resistance is associated with the incidence of diabetes and cardiovascular diseases such as myocardial infarction. The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) (TG/HDL-C ratio) is positively correlated with insulin resistance. This study aimed to investigate the relationship between the TG/HDL-C ratio and the incidence of diabetes in Korean adults. This retrospective study used data from the National Health Insurance Service-National Health Screening Cohort. The TG/HDL-C ratio was divided into three tertiles, the T1, T2, and T3 groups, based on sex. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for diabetes using multivariate Cox proportional hazards regression analyses. A total of 80,693 subjects aged between 40 and 79 years were enrolled. The median follow-up period was 5.9 years. The estimated cumulative incidence of diabetes in the T1, T2, and T3 groups was 5.94%, 8.23%, and 13.50%, respectively, in men and 4.12%, 4.72%, and 6.85%, respectively, in women. Compared to T1, the fully adjusted HRs (95% CIs) of the T2 and T3 groups for new-onset diabetes were 1.17 (1.06–1.30) and 1.47 (1.34–1.62), respectively, in men and 1.20 (1.02–1.42) and 1.52 (1.30–1.78), respectively, in women. Increased TG/HDL-C ratio was significantly associated with a higher risk of new-onset diabetes in both sexes. The online version contains supplementary material available at 10.1186/s12933-021-01377-5.
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