Rethinking Nuclear Receptors as Potential Therapeutic Targets for Retinal Diseases.
Rethinking Nuclear Receptors as Potential Therapeutic Targets for Retinal Diseases.
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DOI：
10.1177/1087057116659856
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发表时间：
2016-12
影响因子：
--
通讯作者：
Malek G
中科院分区：
文献类型：
--
作者：
Choudhary M;Malek G
总的来说，视网膜疾病，包括年龄相关性黄斑变性、色素性视网膜炎和糖尿病性视网膜病变，在世界范围内导致严重的视力损害。这些致盲性疾病的成功药物治疗的缺乏和/或有限的可用性需要进一步了解其病理生物学和确定新的靶向信号通路。核受体是人类生理学以及病理生理学的许多关键方面的转录调节因子，在发育、衰老和疾病中具有报道的作用。由核受体调节的一些途径包括但不限于血管生成、炎症和脂质代谢失调，这些机制在几种视网膜疾病的起始和发展中也很重要。在此，我们提出了一个概述的生物学三种疾病影响后眼，总结了越来越多的证据表明，直接或间接参与疾病进展的核受体，并讨论了靶向核受体治疗的治疗潜力。
Collectively, retinal diseases, including age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy, result in severe vision impairment worldwide. The absence and/or limited availability of successful drug therapies for these blinding disorders necessitates further understanding their pathobiology and identifying new targetable signaling pathways. Nuclear receptors are transcription regulators of many key aspects of human physiology, as well as pathophysiology, with reported roles in development, aging, and disease. Some of the pathways regulated by nuclear receptors include, but are not limited to, angiogenesis, inflammation, and lipid metabolic dysregulation, mechanisms also important in the initiation and development of several retinal diseases. Herein, we present an overview of the biology of three diseases affecting the posterior eye, summarize a growing body of evidence that suggests direct or indirect involvement of nuclear receptors in disease progression, and discuss the therapeutic potential of targeting nuclear receptors for treatment.
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影响因子：
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作者：
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