Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
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DOI：
10.3748/wjg.v24.i11.1239
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发表时间：
2018-03-21
影响因子：
4.3
通讯作者：
Tanaka E
中科院分区：
文献类型：
--
作者：
Fujimori N;Umemura T;Kimura T;Tanaka N;Sugiura A;Yamazaki T;Joshita S;Komatsu M;Usami Y;Sano K;Igarashi K;Matsumoto A;Tanaka E
研究非酒精性脂肪性肝病 (NAFLD) 患者血清自分泌运动因子 (ATX) 浓度与临床病理结果之间的关系。回顾性纳入 2008 年至 2017 年间接受肝活检的 186 名 NAFLD 患者。在活检时收集血清样本，并通过酶免疫测定法测量 ATX。取自 160 名健康、非肥胖个体的血清用作对照。根据 NAFLD 评分系统对组织学结果进行分级，并通过 Spearman 检验计算与血清 ATX 的相关性。使用受试者工作特征曲线下面积（AUC）评估诊断准确性。截止值由约登指数确定，最接近临床适用值的截止值被认为是临床便利性的最佳阈值。 NAFLD 患者的血清 ATX 水平显着高于对照组（0.86 mg/L vs 0.76 mg/L，P < 0.001），并且与气球评分和纤维化阶段显着相关（分别为 r = 0.36，P < 0.001 和 r = 0.45，P < 0.001）。这种倾向在女性患者中更为强烈。 ATX 与血清丙氨酸氨基转移酶、血脂谱或脂肪变性评分之间没有显着关系。在各自的分析中，ATX 用于预测纤维化（≥ F1）、显着纤维化（≥ F2）、严重纤维化（≥ F3）和肝硬化（F4）存在的 AUC 值均超过 0.70。血清 ATX 水平可能至少部分反映 NAFLD 的组织学严重程度。
To examine the relationship between serum autotaxin (ATX) concentrations and clinicopathological findings in non-alcoholic fatty liver disease (NAFLD) patients. One hundred eighty-six NAFLD patients who had undergone liver biopsy between 2008 and 2017 were retrospectively enrolled. Serum samples were collected at the time of biopsy and ATX was measured by enzyme immunoassays. Sera obtained from 160 healthy, non-obese individuals were used as controls. Histological findings were graded according to an NAFLD scoring system and correlations with serum ATX were calculated by Spearman’s test. Diagnostic accuracy was evaluated using the area under the receiver operating characteristic curve (AUC). Cut-off values were identified by the Youden index, and the nearest clinically applicable value to the cutoff was considered the optimal threshold for clinical convenience. Serum ATX levels were significantly higher in NAFLD patients than in controls (0.86 mg/L vs 0.76 mg/L, P < 0.001) and correlated significantly with ballooning score and fibrosis stage (r = 0.36, P < 0.001 and r = 0.45, P < 0.001, respectively). Such tendencies were stronger in female patients. There were no remarkable relationships between ATX and serum alanine aminotransferase, lipid profiles, or steatosis scores. The AUC values of ATX for predicting the presence of fibrosis (≥ F1), significant fibrosis (≥ F2), severe fibrosis (≥ F3), and cirrhosis (F4), were all more than 0.70 in respective analyses. Serum ATX levels may at least partially reflect histological severity in NAFLD.
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DOI：
10.1165/rcmb.2012-0004oc
发表时间：
2012-11-01
影响因子：
6.4
作者：
Oikonomou, Nikos;Mouratis, Marios-Angelos;Aidinis, Vassilis
通讯作者：
Aidinis, Vassilis
影响因子：
4.3
作者：
Kitabatake H;Tanaka N;Fujimori N;Komatsu M;Okubo A;Kakegawa K;Kimura T;Sugiura A;Yamazaki T;Shibata S;Ichikawa Y;Joshita S;Umemura T;Matsumoto A;Koinuma M;Sano K;Aoyama T;Tanaka E
通讯作者：
Tanaka E
DOI：
10.1152/ajpgi.00301.2011
发表时间：
2012-01-01
影响因子：
4.5
作者：
Kakisaka, Keisuke;Cazanave, Sophie C.;Gores, Gregory J.
通讯作者：
Gores, Gregory J.
影响因子：
7.4
作者：
Awada, Rana;Rondeau, Philippe;Bourdon, Emmanuel
通讯作者：
Bourdon, Emmanuel
影响因子：
4.8
作者：
D'Souza, Kenneth;Kane, Daniel A.;Kienesberger, Petra C.
通讯作者：
Kienesberger, Petra C.