The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.
复制标题
DOI：
10.1016/j.nlm.2011.08.003
复制
发表时间：
2011-11
影响因子：
2.7
通讯作者：
Klein, William L.
中科院分区：
文献类型：
--
作者：
Ferreira, Sergio T.;Klein, William L.
Alzheimer's disease is the 3rd most costly disease and is estimated to be the 6th leading cause of death. Alzheimer's disease (AD) is fatal and affected individuals can sometimes linger many years. Current treatments are palliative and transient, not disease modifying. This article reviews progress in the search to identify the primary AD-causing toxins. We summarize the shift from an initial focus on amyloid plaques to the contemporary concept that AD memory failure is caused by small soluble oligomers of the Aβ peptide, toxins that target and disrupt particular synapses. Evidence is presented that links Aβ oligomers to pathogenesis in animal models and humans, with reference to seminal discoveries from cell biology and new ideas concerning pathogenic mechanisms. These findings have established the oligomer hypothesis as a new molecular basis for the cause, diagnosis, and treatment of AD.
登录
查看更多内容
影响因子：
6.1
作者：
Almeida, CG;Tampellini, D;Gouras, GK
通讯作者：
Gouras, GK
影响因子：
5.3
作者：
Abbott, MA;Wells, DG;Fallon, JR
通讯作者：
Fallon, JR
影响因子：
16.2
作者：
Ashe, Karen H.;Zahs, Kathleen R.
通讯作者：
Zahs, Kathleen R.
DOI：
10.1073/pnas.85.8.2790
发表时间：
1988-04-01
影响因子：
11.1
作者：
ALLSOP, D;WONG, CW;GLENNER, GG
通讯作者：
GLENNER, GG
DOI：
10.1073/pnas.90.2.567
发表时间：
1993-01-15
影响因子：
11.1
作者：
ARISPE, N;ROJAS, E;POLLARD, HB
通讯作者：
POLLARD, HB