Monocyte HLA-DR in sepsis: shall we stop following the flow?

Monocyte HLA-DR in sepsis: shall we stop following the flow?
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DOI:
10.1186/cc13179
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发表时间:
2014-01-06
期刊:
Critical care (London, England)
影响因子:
--
通讯作者:
Venet F
Venet F
中科院分区:
其他
文献类型:
--
作者:
Monneret G;Venet F

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迄今为止,用于监测危重患者(败血症、创伤、胰腺炎、手术、烧伤)中免疫改变的最佳标志物仍然是通过流式细胞术测量的单核细胞上HLA-DR表达降低,因为它定期提供死亡率预测或继发感染风险评估方面的有价值信息。正如Cajander及其同事在最近一期的《重症监护》杂志上所展示的那样,一些有前途的基于工具的分子生物学可能会规避与流式细胞术相关的一些缺点。在此,有关这一替代方案的问题和观点进行了讨论。
The best marker for the monitoring of immune alterations in critically ill patients (sepsis, trauma, pancreatitis, surgery, burns) so far remains decreased HLA-DR expression on monocytes measured by flow cytometry as it regularly provides valuable information in terms of mortality prediction or evaluation of risk for secondary infections. As shown by Cajander and colleagues in a recent issue of Critical Care, some promising tools-based molecular biology may circumvent some drawbacks related to flow cytometry. Herein, issues and perspectives about this alternative are discussed.
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发表时间: 2013-01-01
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