Role of the medial and lateral parabrachial nucleus in acquisition and retention of conditioned taste aversion in rats
Role of the medial and lateral parabrachial nucleus in acquisition and retention of conditioned taste aversion in rats
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内侧和外侧臂旁核在大鼠条件性味觉厌恶的获得和保留中的作用
DOI：
10.1016/s0166-4328(97)00133-2
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发表时间：
1998
影响因子：
2.7
通讯作者：
Takashi Yamamoto
中科院分区：
文献类型：
--
作者：
N. Sakai;Takashi Yamamoto
当摄入的味觉刺激与内部不适配对时，动物会记住味道并拒绝摄入。这种学习被称为条件性味觉厌恶（CTA）。为了在成年雄性Wistar大鼠中建立CTA，分别使用0.1%糖精和腹腔注射0.15 M LiCl作为条件和非条件刺激。为了阐明臂旁核（PBmed）的内侧部分接收味觉信息和外侧部分（PBlat）接收一般内脏信息的功能作用，对这些区域中的任何一个进行了限制性电解损伤。双侧PBlat损伤的大鼠损害CTA的收购，但收购CTA后的这些损害没有影响这种学习的保留。双侧PBmed病变使CTA的获取和保留丧失。PBat损伤组大鼠表现出正常的味觉偏好行为，但PBmed-damage组大鼠对味觉刺激的敏感性受损。这些结果表明，PBlat和PBmed都是必要的获得味觉厌恶的学习，但PBlat是不必要的检索CTA。
When ingestion of a taste stimulus is paired with internal malaise, the animal remembers the taste and rejects its ingestion thereafter. This learning is referred to as conditioned taste aversion (CTA). To establish CTA in adult male Wistar rats, 0.1% saccharin and an i.p. injection of 0.15 M LiCl were used as the conditioned and unconditioned stimuli, respectively. To elucidate the functional role of the medial part of the parabrachial nucleus (PBmed) which receives taste information and the lateral part (PBlat) which receives general visceral information, confined electrolytic lesions were made to either of these regions. Rats with bilateral lesions of the PBlat impaired the acquisition of CTA, but those lesions made after the acquisition of CTA had no effect on the retention of this learning. The bilateral lesions of the PBmed abolished the acquisition and retention of CTA. The PBlat-lesioned rats showed normal taste preference behavior, but PBmed-lesioned rats showed impaired sensibility to taste stimuli. These results suggest that both the PBlat and PBmed are essential for the acquisition of taste aversion learning, but the PBlat is not necessary for retrieval of CTA.
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