Pairing mild stress with increased serotonin-1B receptor expression in the nucleus accumbens increases susceptibility to amphetamine.
Pairing mild stress with increased serotonin-1B receptor expression in the nucleus accumbens increases susceptibility to amphetamine.
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DOI：
10.1111/j.1460-9568.2009.06933.x
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Neumaier JF
中科院分区：
文献类型：
--
作者：
Ferguson SM;Sandygren NA;Neumaier JF
5-羟色胺-1B（5-HT 1B）受体和压力调节精神兴奋剂药物的行为和神经生物学效应。为了研究这些因素如何相互作用，以影响成瘾相关行为的发展，我们使用病毒介导的基因转移，短暂增加5-HT 1B受体的表达，在核丘脑（NAc）外壳沿着暴露于反复的轻度应激（新奇+盐水注射）在大鼠。一旦病毒介导的基因表达的增加已经消失，这种5-HT 1B-应激配对对安非他明的急性运动反应和精神过敏的发展产生的影响进行了检查。我们报告说，增加5-HT 1B受体的表达NAC壳神经元，项目的腹侧被盖区和反复暴露大鼠轻度应激的终端随后增强急性运动激活安非他明的影响。此外，促进了心理敏感化的发展-运动活动和刻板成分。这些结果表明，通过NAc 5-HT 1B异源受体的5-羟色胺信号传导可以与压力相互作用，以增加对与成瘾相关的持久形式的药物诱导的可塑性的易感性。
Both serotonin-1B (5-HT1B) receptors and stress modulate the behavioral and neurobiological effects of psychostimulant drugs. In order to examine how these factors interact to influence the development of behaviors associated with addiction, we used viral-mediated gene transfer to transiently increase expression of 5-HT1B receptors in the nucleus accumbens (NAc) shell along with exposure to repeated mild stress (novelty + saline injection) in rats. Once the viral-mediated increases in gene expression had dissipated, the resulting effects of this 5-HT1B-stress pairing on the acute locomotor response to amphetamine and on the development of psychomotor sensitization were examined. We report that increasing expression of 5-HT1B receptors on the terminals of NAc shell neurons that project to the VTA and repeatedly exposing rats to mild stress subsequently enhances the acute locomotor activating effects of amphetamine. In addition, the development of psychomotor sensitization–both locomotor activity and stereotypy components - is facilitated. These results suggest that serotonin signaling through NAc 5-HT1B heteroreceptors can interact with stress to increase susceptibility to enduring forms of drug-induced plasticity that are associated with addiction.
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DOI：
10.1111/j.1440-1681.1995.tb01947.x
发表时间：
1995-11-01
影响因子：
2.9
作者：
CAMERON, DL;WILLIAMS, JT
通讯作者：
WILLIAMS, JT
影响因子：
10.6
作者：
Ferguson, Susan M.;Mitchell, Ellen S.;Neumaier, John F.
通讯作者：
Neumaier, John F.
影响因子：
25
作者：
Kreek, MJ;Nielsen, DA;LaForge, KS
通讯作者：
LaForge, KS
影响因子：
5.3
作者：
Clark, MS;Sexton, TJ;Neumaier, JF
通讯作者：
Neumaier, JF
影响因子：
3.6
作者：
Morikawa, H;Manzoni, OJ;Williams, JT
通讯作者：
Williams, JT