Peripheral T-cell tolerance in hosts with acute myeloid leukemia.
Peripheral T-cell tolerance in hosts with acute myeloid leukemia.
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DOI:
10.4161/onci.25445
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发表时间:
2013-08-01
期刊:
影响因子:
7.2
通讯作者:
Kline J
中科院分区:
文献类型:
--
作者:
Chen X;Kline DE;Kline J
Our laboratory investigates the immune tolerance mechanisms promoted by acute myeloid leukemia (AML). In a murine AML model, we have observed that leukemia antigen-specific T cells are specifically deleted from the host, presumably following interactions with immature host antigen-presenting cells (APCs). Ongoing work focuses on identifying APC subsets that induce T-cell tolerance in AML as well as the precise mechanisms that underlie this phenomenon.
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