With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.
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DOI：
10.1016/j.cmet.2010.05.001
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发表时间：
2010-06-09
期刊：
影响因子：
29
通讯作者：
Kockel L
中科院分区：
文献类型：
--
作者：
Kapahi P;Chen D;Rogers AN;Katewa SD;Li PW;Thomas EL;Kockel L
雷帕霉素靶蛋白（TOR）是一种进化上保守的营养敏感蛋白激酶，在所有真核细胞中调节生长和代谢。对苍蝇、蠕虫、酵母和小鼠的研究支持TOR信号网络在调节衰老中起关键作用的观点。TOR正在成为各种形式的饮食限制（DR）的保护作用的最强大的介质，已被证明可以延长寿命并减缓某些与年龄相关的疾病的发生。在这里，我们讨论了如何调节TOR信号网络通过影响许多下游过程来减缓衰老，包括mRNA翻译，自噬，内质网（ER）应激信号传导，应激反应和代谢。确定TOR信号网络作为衰老起搏器的机制是该领域的一个主要挑战，可能有助于确定年龄相关疾病的潜在药物靶点，从而促进人类健康的寿命延长。
TOR (target of rapamycin) is an evolutionarily conserved nutrient sensing protein kinase that regulates growth and metabolism in all eukaryotic cells. Studies in flies, worms, yeast and mice support the notion that the TOR signaling network plays a pivotal role in modulating aging. TOR is emerging as the most robust mediator of the protective effects of various forms of dietary restriction (DR), which has been shown to extend lifespan and slow the onset of certain age-related diseases across species. Here we discuss how modulating the TOR signaling network slows aging by affecting a number of downstream processes including mRNA translation, autophagy, endoplasmic reticulum (ER) stress signaling, stress responses and metabolism. Identifying the mechanisms by which the TOR signaling network works as a pacemaker of aging is a major challenge in the field and may help identify potential drug targets for age–related diseases thereby facilitating healthful lifespan extension in humans.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
2.1
作者：
CHIPPINDALE, AK;LEROI, AM;ROSE, MR
通讯作者：
ROSE, MR
影响因子：
56.9
作者：
Clancy, DJ;Gems, D;Partridge, L
通讯作者：
Partridge, L
影响因子：
64.8
作者：
Bernardi, Rosa;Guernah, Ilhem;Pandolfi, Pier Paolo
通讯作者：
Pandolfi, Pier Paolo
影响因子：
9.2
作者：
Copeland, Jeffrey M.;Cho, Jaehyoung;Walker, David W.
通讯作者：
Walker, David W.