C-reactive protein, interleukin-6, soluble tumor necrosis factor α receptor 2 and incident clinical depression.
C-reactive protein, interleukin-6, soluble tumor necrosis factor α receptor 2 and incident clinical depression.
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DOI：
10.1016/j.jad.2014.03.023
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发表时间：
2014-07
影响因子：
6.6
通讯作者：
Ascherio A
中科院分区：
文献类型：
--
作者：
Chocano-Bedoya PO;Mirzaei F;O'Reilly EJ;Lucas M;Okereke OI;Hu FB;Rimm EB;Ascherio A
尽管有大量关于炎症和抑郁症作用的文献，但很少有研究以前瞻性的方式评估炎症生物标志物和抑郁症之间的关联，结果是不确定的。我们对4,756名参加护士健康研究的女性进行了一项前瞻性分析，这些女性在1990年献血，1996年之前没有抑郁症。参与者在1996年至2008年期间接受了临床诊断抑郁症或抗抑郁药使用报告的随访。此外，我们对CRP、IL-6和TNFα-R2以及抽血时抗抑郁药的使用情况进行了横断面分析。在对体重指数、绝经状态、抗炎药使用和其他协变量进行校正后，在随访6-18年后，未观察到CRP、IL-6和TNFα-R2与抑郁事件之间的显著相关性。然而，绝经状态似乎改变了IL-6和抑郁症风险之间的关联。在横断面分析中，TNFα-R2与抗抑郁药使用相关（OR=1.96，95% CI=1.23-3.13，P趋势=0.001），但未发现CRP和IL-6的显著相关性。1996年，在抽血6年后，首次评估了抑郁症的诊断。然而，这些生物标志物与相隔4年的测量结果具有很高的人内相关性。在6-18年的随访中，CRP、IL-6和TNFα-R2的血液水平与抑郁事件无关。在横断面分析中，抗抑郁药的使用可能与较高水平的TNFα-R2相关，但在前瞻性分析中未观察到与抑郁或抗抑郁药的使用相关。
Despite an extensive literature on the role of inflammation and depression, few studies have evaluated the association between inflammatory biomarkers and depression in a prospective manner, and results are inconclusive. We conducted a prospective analysis of blood levels of CRP, IL-6 and TNFα-R2 in 4,756 women participating in the Nurses’ Health Study who donated blood in 1990 and were depression-free up to 1996. Participants were followed between 1996 and 2008 for reports of clinical diagnosis depression or antidepressant use. Additionally, we conducted cross-sectional analyses for CRP, IL-6 and TNFα-R2 and antidepressant use at time of blood draw. After adjustment for body mass index, menopause status, use of anti-inflammatory drugs and other covariates, no significant associations between CRP, IL-6 and TNFα-R2 and incident depression were observed after a follow-up of 6-18 years. However, menopause status appears to modify the association between IL-6 and depression risk. In cross-sectional analyses, TNFα-R2 was associated with antidepressant use (OR=1.96, 95% CI=1.23-3.13, P-trend=0.001), but no significant associations were found for CRP and IL-6. Depression diagnosis was first assessed in 1996, 6 years after blood draw. However the biomarkers have high within-person correlations with measurements 4 years apart. Blood levels of CRP, IL-6 and TNFα-R2 were not associated with incident depression over a follow-up of 6-18 years. In cross-sectional analyses, antidepressant use may be associated with higher levels of TNFα-R2 but no associations with depression or antidepressant use were observed in the prospective analysis.
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