Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.
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DOI：
10.1016/j.neuroscience.2013.04.060
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发表时间：
2013-08-29
期刊：
影响因子：
3.3
通讯作者：
Lotrich FE
中科院分区：
文献类型：
--
作者：
Felger JC;Lotrich FE
越来越多的证据表明，炎性细胞因子在患有疾病和身体健康的个体中都参与了抑郁症的发展。细胞因子对发育和正常的大脑功能很重要，并且能够影响神经回路和神经递质系统，从而产生行为改变。在急性情况下，炎性细胞因子的施用或先天免疫系统的激活会产生适应性行为反应，促进能量的保存以对抗感染或从损伤中恢复。然而，长期暴露于升高的炎性细胞因子以及神经递质系统的持续改变会导致神经精神疾病和抑郁症。细胞因子行为效应的机制涉及大脑中炎性信号通路的激活，这导致单胺、谷氨酸和神经肽系统的变化，以及生长因子（例如脑源性神经营养因子）的减少。此外，炎性细胞因子可能作为环境（例如童年创伤、肥胖、压力和睡眠不良）和遗传（功能基因多态性）因素的介质，这些因素都参与了抑郁症的发展。这篇综述探讨了特定基因多态性和神经递质系统可以赋予对细胞因子相关抑郁症的特定症状维度的保护或易感性这一观点。此外，还讨论了针对炎性细胞因子信号传导或细胞因子对大脑中神经递质系统的影响以预防或逆转细胞因子对行为的影响的潜在治疗策略。
Mounting evidence indicates that inflammatory cytokines contribute to the development of depression in both medically ill and medically healthy individuals. Cytokines are important for development and normal brain function, and have the ability to influence neurocircuitry and neurotransmitter systems to produce behavioral alterations. Acutely, inflammatory cytokine administration or activation of the innate immune system produces adaptive behavioral responses that promote conservation of energy to combat infection or recovery from injury. However, chronic exposure to elevated inflammatory cytokines and persistent alterations in neurotransmitter systems can lead to neuropsychiatric disorders and depression. Mechanisms of cytokine behavioral effects involve activation of inflammatory signaling pathways in the brain that results in changes in monoamine, glutamate, and neuropeptide systems, and decreases in growth factors, e.g. brain derived neurotrophic factor. Furthermore, inflammatory cytokines may serve as mediators of both environmental (e.g. childhood trauma, obesity, stress, and poor sleep) and genetic (functional gene polymorphisms) factors that contribute to depression’s development. This review explores the idea that specific gene polymorphisms and neurotransmitter systems can confer protection from or vulnerability to specific symptom dimensions of cytokine-related depression. Additionally, potential therapeutic strategies that target inflammatory cytokine signaling or the consequences of cytokines on neurotransmitter systems in the brain to prevent or reverse cytokine effects on behavior are discussed.
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影响因子：
11
作者：
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通讯作者：
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