S100B levels are affected by older age but not by alcohol intoxication following mild traumatic brain injury.
S100B levels are affected by older age but not by alcohol intoxication following mild traumatic brain injury.
复制标题
DOI：
10.1186/1757-7241-21-52
复制
发表时间：
2013-07-06
期刊：
影响因子：
--
通讯作者：
Undén J
中科院分区：
文献类型：
--
作者：
Calcagnile O;Holmén A;Chew M;Undén J
脑损伤和头部损伤的生物标志物是管理患病患者的潜在有用工具。特别是S100 B受到了广泛关注，并已被改编为临床指南。酒精中毒和较高的年龄（65岁及以上）已被用作头部损伤后严重并发症的风险因素。这些因素对S100 B水平的影响尚未在相关患者队列中完全确定。我们前瞻性纳入了621例轻度创伤性脑损伤（TBI）和S100 B采样的成人患者。轻度TBI定义为格拉斯哥Come量表14-15，伴有意识丧失和/或遗忘，但无颅内并发症的高危因素。这些患者通常需要根据当地和大多数国际指南进行CT扫描。S100 B在创伤后3小时内取样。酒精中毒280例（45%）。酒精中毒对S100 B水平没有影响（p = 0.65），这些患者的S100 B性能保持不变。115例患者（22%）为65岁或以上，与65岁以下的患者相比，该组中S100 B水平升高更常见（p = 0.029）。尽管S100 B在老年患者中的敏感性没有变化，但特异性较差。S100 B可可靠地用于轻度TBI合并酒精中毒患者。S100 B在老年患者中的临床应用可能受到特异性极差的限制，导致CT扫描仅略有减少。
Biomarkers of brain damage and head injury are potentially useful tools in the management of afflicted patients. Particularly S100B has received much attention and has been adapted into clinical guidelines. Alcohol intoxication and higher age (65 years and over) have been used as risk factors for serious complications following head injury. The effect of these factors on S100B levels has not been fully established in a relevant patient cohort. We prospectively included 621 adult patients with mild traumatic brain injury (TBI) and S100B sampling. Mild TBI was defined as Glasgow Come Scale 14–15 with loss of consciousness and/or amnesia, but without high-risk factors for intracranial complications. These patients would normally require CT scanning according to local and most international guidelines. S100B was sampled within 3 hours following trauma. 280 patients (45%) were intoxicated by alcohol. Alcohol intoxication had no effect on S100B levels (p = 0.65) and the performance of S100B remained unchanged in these patients. 115 patients (22%) were 65 years or older with elevated S100B levels being more common in this group compared to patients under 65 (p = 0.029). Although the sensitivity of S100B was unchanged in older patients, the specificity was poorer. S100B can be used reliably in mild TBI patients with alcohol intoxication. The clinically utility of S100B in older patients may be limited by very poor specificity leading to only a small decrease in CT scanning.
登录
查看更多内容
DOI：
10.1097/ta.0b013e318047bfaa
发表时间：
2007-06-01
影响因子：
--
作者：
Muller, Kay;Townend, Will;Ingebrigtsen, Tor
通讯作者：
Ingebrigtsen, Tor
影响因子：
9.3
作者：
Undén J;Ingebrigtsen T;Romner B;Scandinavian Neurotrauma Committee (SNC)
通讯作者：
Scandinavian Neurotrauma Committee (SNC)
影响因子：
2.8
作者：
Cervellin, Gianfranco;Benatti, Mario;Lippi, Giuseppe
通讯作者：
Lippi, Giuseppe
影响因子：
168.9
作者：
Stiell, IG;Wells, GA;Worthington, J
通讯作者：
Worthington, J
影响因子：
2.4
作者：
Lange, Rael T.;Iverson, Grant L.;Brubacher, Jeffrey R.
通讯作者：
Brubacher, Jeffrey R.