Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2.
Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2.
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DOI：
10.1016/j.celrep.2021.108790
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发表时间：
2021-03-02
期刊：
影响因子：
8.8
通讯作者：
Finzi A
中科院分区：
文献类型：
--
作者：
Gasser R;Cloutier M;Prévost J;Fink C;Ducas É;Ding S;Dussault N;Landry P;Tremblay T;Laforce-Lavoie A;Lewin A;Beaudoin-Bussières G;Laumaea A;Medjahed H;Larochelle C;Richard J;Dekaban GA;Dikeakos JD;Bazin R;Finzi A
对SARS-CoV-2（COVID-19的病原体）的体液反应的表征对于帮助控制感染至关重要。COVID-19患者血浆的中和活性在康复后的最初几周内迅速下降。然而，每种免疫球蛋白同种型在总体中和能力中的具体作用仍不清楚。在这项研究中，我们从COVID-19康复期患者队列中选择血浆，并选择性地消耗免疫球蛋白A、M或G，然后测试消耗后血浆的剩余中和能力。我们发现免疫球蛋白M的消耗与病毒中和作用的最大损失相关，其次是免疫球蛋白G。这一观察结果可能有助于设计有效的基于抗体的COVID-19疗法，也可能解释接受损害免疫球蛋白M（IgM）产生的疗法的自身免疫患者对SARS-CoV-2的易感性增加。Gasser等人强调了IgM在恢复期捐献者血浆中和SARS-CoV-2能力中的重要性。
Characterization of the humoral response to SARS-CoV-2, the etiological agent of COVID-19, is essential to help control the infection. The neutralization activity of plasma from patients with COVID-19 decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we select plasma from a cohort of convalescent patients with COVID-19 and selectively deplete immunoglobulin A, M, or G before testing the remaining neutralizing capacity of the depleted plasma. We find that depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of immunoglobulin M (IgM). Gasser et al. highlight the importance of IgM in the capacity of plasma from convalescent donors to neutralize SARS-CoV-2.
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
3
作者：
Bergmann-Leitner ES;Mease RM;Duncan EH;Khan F;Waitumbi J;Angov E
通讯作者：
Angov E
影响因子：
3.6
作者：
Dimitrov, Jordan D.;Lacroix-Desmazes, Sebastien;Vassilev, Tchavdar L.
通讯作者：
Vassilev, Tchavdar L.
影响因子：
8.6
作者：
St-Amour, Isabelle;Laroche, Andre;Lemieux, Real
通讯作者：
Lemieux, Real
DOI：
10.1016/j.xcrm.2020.100126
发表时间：
2020-10-20
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Prévost J;Gasser R;Beaudoin-Bussières G;Richard J;Duerr R;Laumaea A;Anand SP;Goyette G;Benlarbi M;Ding S;Medjahed H;Lewin A;Perreault J;Tremblay T;Gendron-Lepage G;Gauthier N;Carrier M;Marcoux D;Piché A;Lavoie M;Benoit A;Loungnarath V;Brochu G;Haddad E;Stacey HD;Miller MS;Desforges M;Talbot PJ;Maule GTG;Côté M;Therrien C;Serhir B;Bazin R;Roger M;Finzi A
通讯作者：
Finzi A