Sexualized drug use ('chemsex') and high-risk sexual behaviours in HIV-positive men who have sex with men.
Sexualized drug use ('chemsex') and high-risk sexual behaviours in HIV-positive men who have sex with men.
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DOI：
10.1111/hiv.12574
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发表时间：
2018-04
期刊：
影响因子：
3
通讯作者：
Positive Voices study group
中科院分区：
文献类型：
--
作者：
Pufall EL;Kall M;Shahmanesh M;Nardone A;Gilson R;Delpech V;Ward H;Positive Voices study group
在英国，同性恋、双性恋和其他男男性行为者（MSM）的性传播感染（STI）和艾滋病毒感染的发病率仍然很高，性化药物使用（“chemsex”）和注射药物使用（“slamsex”）可能在其中发挥作用。我们的目的是描述艾滋病毒阳性的男男性接触者从事化学性行为/性行为，并评估与自我报告的性病诊断和性行为的关联。2014年对英格兰和威尔士艾滋病诊所就诊者的调查数据与国家艾滋病监测记录的临床数据相关联，并加权以具有全国代表性。多变量logistic回归评估了化学性行为和猛烈性行为与自我报告的无保护肛交（UAI）、血清不一致UAI（sdUAI）（即UAI与HIV阴性或HIV状态未知的伴侣）、sdUAI与可检测的病毒载量（>50 HIV-1 RNA拷贝/mL）、丙型肝炎和细菌性STI的相关性。在过去的一年里，392名性活跃的参与者中有29.5%从事化学性行为，10.1%从事猛烈性行为。化疗性行为与UAI [校正比值比（AOR）5.73; P < 0.001]、sdUAI（AOR 2.34; P < 0.05）、sdUAI伴可检测病毒载量（AOR 3.86; P < 0.01）、丙型肝炎（AOR 6.58; P < 0.01）和细菌性STI诊断（AOR 2.65; P < 0.01）的比值增加显著相关。猛烈性交与UAI（AOR 6.11; P < 0.05）、丙型肝炎（AOR 9.39; P < 0.001）和细菌性STI诊断（AOR 6.11; P < 0.001）的几率增加相关。在过去的一年中，十分之三的性活跃的HIV阳性MSM参与了化学性行为，这与自我报告的抑郁/焦虑，吸烟，非性药物使用，危险的性行为，性传播感染和丙型肝炎呈正相关。因此，Chemsex可能在英国持续的艾滋病毒和性传播感染流行中发挥作用。
The incidence of sexually transmitted infections (STIs) and HIV infection remains high in gay, bisexual, and other men who have sex with men (MSM) in the UK, and sexualized drug use (“chemsex”) and injecting drug use (“slamsex”) may play a part in this. We aimed to characterize HIV‐positive MSM engaging in chemsex/slamsex and to assess the associations with self‐reported STI diagnoses and sexual behaviours. Data from a 2014 survey of people attending HIV clinics in England and Wales were linked to clinical data from national HIV surveillance records and weighted to be nationally representative. Multivariable logistic regression assessed the associations of chemsex and slamsex with self‐reported unprotected anal intercourse (UAI), serodiscordant UAI (sdUAI) (i.e. UAI with an HIV‐negative or unknown HIV status partner), sdUAI with a detectable viral load (>50 HIV‐1 RNA copies/mL), hepatitis C, and bacterial STIs. In the previous year, 29.5% of 392 sexually active participants engaged in chemsex, and 10.1% in slamsex. Chemsex was significantly associated with increased odds of UAI [adjusted odds ratio (AOR) 5.73; P < 0.001], sdUAI (AOR 2.34; P < 0.05), sdUAI with a detectable viral load (AOR 3.86; P < 0.01), hepatitis C (AOR 6.58; P < 0.01), and bacterial STI diagnosis (AOR 2.65; P < 0.01). Slamsex was associated with increased odds of UAI (AOR 6.11; P < 0.05), hepatitis C (AOR 9.39; P < 0.001), and bacterial STI diagnosis (AOR 6.11; P < 0.001). Three in ten sexually active HIV‐positive MSM engaged in chemsex in the past year, which was positively associated with self‐reported depression/anxiety, smoking, nonsexual drug use, risky sexual behaviours, STIs, and hepatitis C. Chemsex may therefore play a role in the ongoing HIV and STI epidemics in the UK.
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影响因子：
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作者：
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通讯作者：
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DOI：
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