Probiotic induced synthesis of microbiota polyamine as a nutraceutical for metabolic syndrome and obesity-related type 2 diabetes.
Probiotic induced synthesis of microbiota polyamine as a nutraceutical for metabolic syndrome and obesity-related type 2 diabetes.
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益生菌诱导的微生物群多胺合成作为代谢综合征和肥胖相关的2型糖尿病的营养药物。
DOI：
10.3389/fendo.2022.1094258
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发表时间：
2022
影响因子：
5.2
通讯作者：
Gill, Steven R. R.
中科院分区：
文献类型：
--
作者：
Bui, Tina I. I.;Britt, Emily A. A.;Muthukrishnan, Gowrishankar;Gill, Steven R. R.
肠道微生物群通过产生信号代谢物（例如多胺）来调节宿主代谢和免疫的多个方面，多胺是对宿主细胞生长和淋巴细胞激活至关重要的小有机化合物。多胺在肠腔中最为丰富，肠道微生物群的合成受到微生物组组成和宿主饮食的影响。代谢综合征和肥胖相关 2 型糖尿病（肥胖/T2D）中宿主肠道微生物组的破坏可能导致多胺合成失调。越来越多的证据表明，恢复失调的肠道微生物群和多胺合成可有效改善代谢综合征并增强肥胖/T2D 受损的免疫反应。在这篇综述中，我们讨论了关于多胺合成的肠道微生物组决定因素、肥胖/T2D 中多胺产生的现有研究，以及证明多胺作为肥胖/T2D 宿主营养保健品潜力的证据。
The gut microbiota regulates multiple facets of host metabolism and immunity through the production of signaling metabolites, such as polyamines which are small organic compounds that are essential to host cell growth and lymphocyte activation. Polyamines are most abundant in the intestinal lumen, where their synthesis by the gut microbiota is influenced by microbiome composition and host diet. Disruption of the host gut microbiome in metabolic syndrome and obesity-related type 2 diabetes (obesity/T2D) results in potential dysregulation of polyamine synthesis. A growing body of evidence suggests that restoration of the dysbiotic gut microbiota and polyamine synthesis is effective in ameliorating metabolic syndrome and strengthening the impaired immune responses of obesity/T2D. In this review, we discuss existing studies on gut microbiome determinants of polyamine synthesis, polyamine production in obesity/T2D, and evidence that demonstrates the potential of polyamines as a nutraceutical in obesity/T2D hosts.
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影响因子：
4.2
作者：
Dowsey, Michelle M.;Choong, Peter F. M.
通讯作者：
Choong, Peter F. M.
影响因子：
24.5
作者：
Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
通讯作者：
Delzenne NM
影响因子：
5.9
作者：
Barrea, Luigi;Annunziata, Giuseppe;Savastano, Silvia
通讯作者：
Savastano, Silvia
影响因子：
2.9
作者：
Çelik VK;Kapancık S;Kaçan T;Kaçan SB;Kapancık S;Kılıçgün H
通讯作者：
Kılıçgün H
DOI：
10.2337/ds17-0030
发表时间：
2017-11
期刊：
Diabetes spectrum : a publication of the American Diabetes Association
影响因子：
--
作者：
Bramante CT;Lee CJ;Gudzune KA
通讯作者：
Gudzune KA