Computational design and in vitro characterization of an integrated maglev pump-oxygenator.
Computational design and in vitro characterization of an integrated maglev pump-oxygenator.
复制标题
集成磁悬浮泵氧合器的计算设计和体外表征。
作者：
Juntao Zhang;M. Taskin;A. Koert;Zhang Tao;B. Gellman;K. Dasse;R. Gilbert;B. Griffith;Zhongjun J. Wu
为了满足急性或慢性肺部疾病患者对呼吸支持的需求，正在开发一种新型集成磁悬浮泵氧合器（IMPO）作为呼吸辅助装置。 IMPO 的概念是将磁悬浮泵/转子与独特配置的中空纤维膜相结合，创建一个免组装的超紧凑系统。 IMPO 是一种独立的血泵和氧合器组件，可以为需要呼吸支持或循环支持的患者快速部署。在这项研究中，通过计算流体动力学（CFD）和计算机辅助设计来设计和优化这种新型装置的血液动力学、气体传输和血液相容性性能。同时，进行了包括流体动力学、气体转移和溶血测量在内的体外实验，以评估 IMPO 的性能。将 CFD 分析的计算结果与 IMPO 体外评估收集的实验数据进行比较。 CFD 模拟表明该装置的主要部件具有良好的流线型流场。通过计算模拟预测的水动力性能、氧传输和溶血结果以及体外实验数据表明，该泵肺装置可以满足肺衰竭成人的总呼吸需求，并且在目标操作条件下溶血率较低。这些详细的 CFD 设计和分析可以为进一步优化该 IMPO 的长期使用提供有价值的指导。
For the need for respiratory support for patients with acute or chronic lung diseases to be addressed, a novel integrated maglev pump-oxygenator (IMPO) is being developed as a respiratory assist device. IMPO was conceptualized to combine a magnetically levitated pump/rotor with uniquely configured hollow fiber membranes to create an assembly-free, ultracompact system. IMPO is a self-contained blood pump and oxygenator assembly to enable rapid deployment for patients requiring respiratory support or circulatory support. In this study, computational fluid dynamics (CFD) and computer-aided design were conducted to design and optimize the hemodynamics, gas transfer, and hemocompatibility performances of this novel device. In parallel, in vitro experiments including hydrodynamic, gas transfer, and hemolysis measurements were conducted to evaluate the performance of IMPO. Computational results from CFD analysis were compared with experimental data collected from in vitro evaluation of the IMPO. The CFD simulation demonstrated a well-behaved and streamlined flow field in the main components of this device. The results of hydrodynamic performance, oxygen transfer, and hemolysis predicted by computational simulation, along with the in vitro experimental data, indicate that this pump-lung device can provide the total respiratory need of an adult with lung failure, with a low hemolysis rate at the targeted operating condition. These detailed CFD designs and analyses can provide valuable guidance for further optimization of this IMPO for long-term use.
开发静脉膜氧合器：通过中空纤维膜周围血液的对流混合来增强静脉内气体交换。
影响因子：
2.4
作者：
Hattler,BG;Reeder,GD;Sawzik,PJ;Lund,LW;Walters,FR;Shah,AS;Rawleigh,J;Goode,JS;Klain,M;Borovetz,HS
通讯作者：
Borovetz,HS