Mechanism and Function of Signaling by the TGFβ Superfamily
Mechanism and Function of Signaling by the TGFβ Superfamily
复制标题
TGFβ 超家族的信号传导机制和功能
DOI：
--
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
J. Wrana
中科院分区：
文献类型：
--
作者：
P. Hoodless;J. Wrana
转化生长因子β (TGFβ)最初是基于其诱导正常大鼠肾成纤维细胞不依赖锚定生长的能力而被发现的（Roberts et al. 1981）。现在很明显，TGFβ是生长和分化因子超家族的创始成员，该家族包括来自秀丽隐杆线虫、果蝇和人类等动物的近40个成员。该超家族通常被细分为三组，即原型TGFβs，激活素和骨形态发生蛋白（BMPs）。然而，随着新成员的不断出现，这些分歧正变得越来越难以界定。然而，对这个大家庭的生物学研究为我们提供了一些有趣和令人惊讶的见解，让我们了解这些因素如何调节一系列惊人的不同发育和生理过程。此外，tgf - β样因子信号传导机制的研究也取得了重大进展。在这篇综述中，我们将重点介绍tgf - β信号传导的最新进展，以及这些因子在发育过程中控制诱导相互作用和模式的多种作用。
Transforming growth factor β (TGFβ) was initially identified based on its ability to induce the anchorage-independent growth of normal rat kidney fibroblasts (Roberts et al. 1981). It is now apparent that TGFβ is the founding member of a superfamily of growth and differentiation factors that includes almost 40 members from animals as diverse as C. elegans, Drosophila and humans. The superfamily is generally subdivided into three groups, the prototypic TGFβs, the activins and the bone morphogenetic proteins (BMPs). However, with new members constantly being identified these divisions are becoming increasingly difficult to define. Nevertheless, the study of the biology of this large family has provided us with some interesting and surprising insights into how these factors can regulate a staggering array of diverse developmental and physiological processes. In addition, major advances have been made in elucidating the mechanism of signaling by TGFβ-like factors. In this review we will focus on recent developments in our understanding of TGFβ signaling and on the multiple roles these factors play in controlling inductive interactions and patterning during development.
登录
查看更多内容
影响因子：
10.5
作者：
Guang-Quan Zhao;Ke-Yu Deng;P. Labosky;Lucy Liaw;Brigid L. M. Hogan
通讯作者：
Guang-Quan Zhao;Ke-Yu Deng;P. Labosky;Lucy Liaw;Brigid L. M. Hogan
影响因子：
10.5
作者：
Baker, JC;Harland, RM
通讯作者：
Harland, RM
哺乳动物矮鳍鱼响应转化生长因子β而被磷酸化，并参与细胞生长的控制。
DOI：
10.1073/pnas.93.17.8940
发表时间：
1996
影响因子：
11.1
作者：
Yingling,JM;Das,P;Savage,C;Zhang,M;Padgett,RW;Wang,XF
通讯作者：
Wang,XF
影响因子：
4.6
作者：
K. Staehling‐Hampton;A. Laughon;F. Hoffmann
通讯作者：
K. Staehling‐Hampton;A. Laughon;F. Hoffmann
激酶缺陷的激活素受体使激活素依赖性转录失活。
DOI：
10.1210/endo.136.12.7588300
发表时间：
1995
期刊：
Endocrinology.
影响因子：
--
作者：
Tsuchida,K;Vaughan,JM;Wiater,E;Gaddy-Kurten,D;Vale,WW
通讯作者：
Vale,WW