Reactogenicity and immunogenicity of a protein-conjugated pneumococcal oligosaccharide vaccine in older adults.

Reactogenicity and immunogenicity of a protein-conjugated pneumococcal oligosaccharide vaccine in older adults.
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蛋白质缀合肺炎球菌寡糖疫苗在老年人中的反应原性和免疫原性。

DOI：
10.1093/infdis/173.4.1014
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发表时间：
1996
期刊：
The Journal of infectious diseases
影响因子：
--
通讯作者：
C. Mink
C. Mink
中科院分区：
--
文献类型：
--
作者：
D. Powers;E. Anderson;Kathleen R. Lottenbach;C. Mink

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≥ 50 岁的健康成人使用五价白喉棒杆菌 C7 (beta197) 交叉反应物质 (CRM197) 蛋白结合肺炎球菌疫苗 (CV) 进行免疫接种，其中含有血清型 6B、14、18C、19F 和 23F 的荚膜寡糖各 10 微克，或使用许可的疫苗（23 价、25 价）进行免疫接种。微克/血清型）肺炎球菌多糖疫苗（PV）。 23 名 CV 接受者中有 20 名发生不良反应，主要是局部性的，而 23 名 PV 接受者中有 13 名发生不良反应 (P<.05)。与 PV 受者的平均疫苗接种后抗体浓度相比，CV 诱导的血清型 6B、14、18C 和 23F 没有显着差异，而 19F 则较低 (P<.05)。六个月后，对最初接受 CV 的受试者进行 PV 重新免疫引起抗体浓度略有升高，达到的水平并不显着高于初次疫苗接种后或给予单剂 PV 的人的水平。对于健康老年人的免疫，含有蛋白质缀合寡糖的肺炎球菌疫苗可能比目前获得许可的含有非缀合多糖的制剂没有任何优势。
Healthy adults > or = 50 years old were immunized with either pentavalent Corynebacterium diphtheriae C7 (beta197) cross-reactive material (CRM197) protein-conjugated pneumococcal vaccine (CV) containing 10 microgram each of capsular oligosaccharides from serotypes 6B, 14, 18C, 19F, and 23F or with licensed (23-valent, 25 microgram/serotype) pneumococcal polysaccharide vaccine (PV). Adverse reactions, predominantly local in nature, occurred in 20 of 23 CV recipients versus 13 of 23 PV recipients (P<.05). Compared with mean postvaccination antibody concentrations in PV recipients, those induced by CV were not significantly different for serotypes 6B, 14, 18C, and 23F and were lower for 19F (P<.05). Six months later, reimmunization with PV of subjects who had initially received CV elicited a slight boost in antibody concentrations to levels that were not significantly higher than those achieved after the primary vaccination or than those in persons given a single dose of PV. Pneumococcal vaccines containing protein-conjugated oligosaccharides may offer no advantage over currently licensed preparations containing unconjugated polysaccharides for immunization of healthy older adults.
Immune response of elderly adults to pneumococcus: variation by age, sex, and functional impairment.
老年人对肺炎球菌的免疫反应：随年龄、性别和功能障碍的变化。
DOI： 10.1093/geronj/42.3.265
发表时间： 1987
期刊： Journal of gerontology
影响因子： --
作者：
Roghmann,KJ;Tabloski,PA;Bentley,DW;Schiffman,G
通讯作者： Schiffman,G
Functional differences in idiotypically defined IgG1 anti-polysaccharide antibodies elicited by vaccination with Haemophilus influenzae type B polysaccharide-protein conjugates.
通过接种 B 型流感嗜血杆菌多糖-蛋白缀合物引起的独特型 IgG1 抗多糖抗体的功能差异。
DOI： --
发表时间： 1995
期刊： Journal of immunology (Baltimore, Md. : 1950)
影响因子： --
作者：
Lucas,AH;Granoff,DM
通讯作者： Granoff,DM