Preparation, structure, drug release and bioinspired mineralization of chitosan-based nanocomplexes for bone tissue engineering
Preparation, structure, drug release and bioinspired mineralization of chitosan-based nanocomplexes for bone tissue engineering
复制标题
用于骨组织工程的壳聚糖纳米复合物的制备、结构、药物释放和仿生矿化
DOI：
10.1016/j.carbpol.2009.04.035
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发表时间：
2009-08
影响因子：
11.2
通讯作者：
Zhou, Changren
中科院分区：
文献类型：
--
作者：
Liu, Hongwei;Zhao, Jianhao;Zha, Zhengang;Zhou, Changren
在温和条件下，通过与三聚磷酸盐（TPP）在不同酸性介质中离子交联制备了不同形态的壳聚糖基纳米配合物。结果表明，反应介质对壳聚糖和TPP的自组装和离子相互作用影响较大，在己二酸介质中可制备壳聚糖基纳米纤维，而在乙酸介质中可制备纳米颗粒。以牛血清白蛋白（BSA）为大分子模型药物，体外药物释放研究表明，壳聚糖纳米纤维和纳米颗粒具有相似的缓释特性。此外，将壳聚糖基纳米纤维和纳米颗粒浸泡在合成体液（SBF）中进行了生物激发矿化。透射电镜（TEM）和x射线衍射（XRD）结果表明，壳聚糖基纳米纤维对纳米羟基磷灰石形成的诱导能力优于壳聚糖基纳米颗粒。结果表明，具有生物活性因子控释能力的仿生壳聚糖基纳米纤维可用于骨组织工程，提高生物活性和骨诱导性。
Chitosan-based nanocomplexes with various forms were prepared by ionically crosslinking with tripolyphosphate (TPP) in different acidic media under mild conditions. It was found that the self-assembly and ionic interactions of chitosan and TPP were greatly affected by reaction media, and chitosan-based nanofibers could be obtained in adipic acid medium while nanoparticles were formed in acetic acid medium. Using bovine serum albumin (BSA) as a macromolecular model-drug, in vitro drug release studies indicated that chitosan-based nanofibers and nanoparticles exhibited a similar prolonged release profile. In addition, the bioinspired mineralization of both chitosan-based nanofibers and nanoparticles was carried out by soaking them in synthetic body fluids (SBF). Transmission electron microscopy (TEM) and X-ray Diffraction (XRD) results indicated that chitosan-based nanofibers have better inductivity for nano-hydroxyapatite formation than chitosan-based nanoparticles. The results suggested that biomimetic chitosan-based nanofibers with controlled release capacity of bioactive factors may be of use in bone tissue engineering for enhancing the bioactivity and bone inductivity.
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影响因子：
9.9
作者：
M. V. Shamov;S. Bratskaya;V. Avramenko
通讯作者：
M. V. Shamov;S. Bratskaya;V. Avramenko
影响因子：
2.8
作者：
B. Karadedeli;A. Bozkurt;A. Baykal
通讯作者：
B. Karadedeli;A. Bozkurt;A. Baykal
DOI：
10.1016/b978-0-08-102999-2.00009-0
发表时间：
2021
期刊：
Bioceramics
影响因子：
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作者：
Semra Unal;F. Oktar;M. Mahiroğulları;O. Gunduz
通讯作者：
Semra Unal;F. Oktar;M. Mahiroğulları;O. Gunduz
影响因子：
0.8
作者：
A. Il’ina;V. Varlamov
通讯作者：
A. Il’ina;V. Varlamov
影响因子：
--
作者：
Ingber, Donald E.;Mow, Van C.;Vunjak-Novakovic, Gordana
通讯作者：
Vunjak-Novakovic, Gordana