Substance use and common contributors to morbidity: A genetics perspective.
Substance use and common contributors to morbidity: A genetics perspective.
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DOI：
10.1016/j.ebiom.2022.104212
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发表时间：
2022-09
期刊：
影响因子：
11.1
通讯作者：
Agrawal, Arpana
中科院分区：
文献类型：
--
作者：
Sanchez-Roige, Sandra;Kember, Rachel L.;Agrawal, Arpana
物质过度使用和物质使用障碍（SUD）是常见的，严重的和复发性的医疗条件。它们经常与其他疾病同时发生，而这些疾病是造成全世界残疾的主要原因。虽然大量使用药物可能会加重其中一些疾病的病程，但越来越多的证据表明存在共同的遗传结构。在这篇叙述性综述中，我们重点关注四种遗传性疾病-心脏代谢疾病、慢性疼痛、抑郁症和COVID-19，这些疾病通常与SUD重叠，但不一定是SUD的直接后果。我们发现了令人信服的证据，表明潜在的遗传易感性易患SUD和慢性疼痛，抑郁症和COVID-19。对于心脏代谢疾病，有更多的支持，潜在的因果关系的影响，有问题的物质使用。我们的审查鼓励去污名化的SUD和评估物质使用的临床环境。我们断言，识别共同的风险途径具有很高的转化潜力，可以为多种医疗条件定制治疗方法。SSR确认T29 KT 0526、T32 IR 5226和DP 1DA 054394; RLK确认AA 028292; AA确认DA 054869和K 02 DA 032573。资助者在论文的概念化或写作中没有任何作用。
Excessive substance use and substance use disorders (SUDs) are common, serious and relapsing medical conditions. They frequently co-occur with other diseases that are leading contributors to disability worldwide. While heavy substance use may potentiate the course of some of these illnesses, there is accumulating evidence suggesting common genetic architectures. In this narrative review, we focus on four heritable medical conditions - cardiometabolic disease, chronic pain, depression and COVID-19, which are commonly overlapping with, but not necessarily a direct consequence of, SUDs. We find persuasive evidence of underlying genetic liability that predisposes to both SUDs and chronic pain, depression, and COVID-19. For cardiometabolic disease, there is greater support for a potential causal influence of problematic substance use. Our review encourages de-stigmatization of SUDs and the assessment of substance use in clinical settings. We assert that identifying shared pathways of risk has high translational potential, allowing tailoring of treatments for multiple medical conditions. SSR acknowledges T29KT0526, T32IR5226 and DP1DA054394; RLK acknowledges AA028292; AA acknowledges DA054869 & K02DA032573. The funders had no role in the conceptualization or writing of the paper.
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影响因子：
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作者：
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DOI：
10.1097/ede.0000000000000314
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期刊：
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