Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement.
Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement.
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DOI：
10.1016/j.phrs.2015.04.003
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发表时间：
2015-07
影响因子：
9.3
通讯作者：
He, Shuangteng
中科院分区：
文献类型：
--
作者：
Grasing, Kenneth;Yang, Yungao;He, Shuangteng
关键词：
我们实验室之前的工作表明，当四天内每天静脉输注给大鼠时，他克林可以长期减少可卡因强化的行为。他克林在不同物种中会引起剂量相关的肝脏毒性，其供人类使用的生产最近已停止。进行这项研究是为了进一步描述其对可卡因奖励的作用。一周内没有接触过药物的可卡因实验动物恢复了自我给药，水平与最初的基线相似。当给予他克林超过四天（之前和之后是清除期以分别消除可卡因和他克林）时，随后的可卡因自我给予减弱了一半以上。通过渗透泵以 10 mg/kg/天的剂量长期输注他克林，不会改变可卡因引起的运动活动或条件位置偏好的增加。在接受他克林后表现出可卡因自我给药持续减弱的大鼠中，可卡因诱导的恢复也减弱。在接受他克林的大鼠中，没有观察到血浆肾功能或肝功能的变化。总之，用他克林进行预处理可以减少通过自我给药或恢复测量的可卡因诱发行为，但不能减少条件性位置偏好。用他克林预处理后可卡因自我给药的减少不需要与可卡因直接相互作用，并且不会继发于肝脏或肾脏毒性。
Previous work by our laboratory has shown that tacrine can produce long-lasting reductions in cocaine-reinforced behavior, when administered to rats as daily intravenous infusions over four days. Tacrine causes dose-related liver toxicity in different species, and its manufacture for human use was recently discontinued. This study was conducted to further characterize its actions on cocaine reward. Cocaine-experienced animals that had no contact with drug over one week resumed self-administration at levels similar to their initial baseline. When tacrine was administered over four days which were preceded and followed by washout periods to allow elimination of cocaine and tacrine respectively, subsequent cocaine self-administration was attenuated by more than one-half. Tacrine administered at 10 mg/kg-day as a chronic infusion by osmotic pump did not modify cocaine-induced increases in locomotor activity or conditioned-place preference. In rats that exhibited persistent attenuation of cocaine-self-administration after receiving tacrine, cocaine-induced reinstatement was also attenuated. No changes in plasma measures of renal or hepatic function were observed in rats receiving tacrine. In conclusion, pretreatment with tacrine can decrease cocaine-motivated behavior measured by self-administration or reinstatement, but not conditioned-place preference. Reductions in cocaine self-administration following pretreatment with tacrine do not require direct interaction with cocaine and are not secondary to either liver or kidney toxicity.
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影响因子：
3.6
作者：
Grasing, Kenneth;He, Shuangteng;Yang, Yungao
通讯作者：
Yang, Yungao
影响因子：
3.4
作者：
Gipson, Cassandra D.;Bardo, Michael T.
通讯作者：
Bardo, Michael T.
影响因子：
3.9
作者：
Goh, Catherine W.;Aw, Chiu Cheong;Browne, Edward R.
通讯作者：
Browne, Edward R.
影响因子：
14.5
作者：
Moeller, Scott J.;Maloney, Thomas;Goldstein, Rita Z.
通讯作者：
Goldstein, Rita Z.
影响因子：
4
作者：
Bermúdez-Rattoni, F;Ramírez-Lugo, L;Miranda, MI
通讯作者：
Miranda, MI