A unified theory of the role of the ocular surface in dry eye.
A unified theory of the role of the ocular surface in dry eye.
复制标题
眼表在干眼症中作用的统一理论。
DOI：
10.1007/978-1-4615-5359-5_91
复制
发表时间：
1998
影响因子：
--
通讯作者：
S. C. Pflugfelder
中科院分区：
文献类型：
--
作者：
Michael E. Stern;R. Beuerman;Robert I. Fox;Jianping Gao;A. Mircheff;S. C. Pflugfelder
It is our belief that the pathology of dry eye occurs when systemic androgen levels fall below the threshold necessary for support of secretory function and generation of an anti-inflammatory environment (Fig. 3). When this occurs, both the lacrimal gland and the ocular surface become irritated and inflamed, and they secrete cytokines that interfere with the normal neural connections that drive the tearing reflex. This leaves the lacrimal gland in an isolated condition, perhaps exacerbating atrophic alterations of the glandular tissue. These changes allow for antigen presentation at the surface of the lacrimal acinar cells and increase lymphocytic infiltration of the gland. A similar series of events may be occurring on the ocular surface. From this hypothesis we conclude: 1. The ocular surface, lacrimal gland, and interconnecting innervation act as an integrated servo-mechanism. 2. Once the lacrimal gland loses its androgen support, it is subject to immune/neurally mediated dysfunction. 3. The ocular surface is an appropriate target for dry eye therapeutics.
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影响因子：
13.7
作者：
J. Pepose;R. F. Akata;S. Pflugfelder;W. Voigt
通讯作者：
J. Pepose;R. F. Akata;S. Pflugfelder;W. Voigt
DOI：
10.1073/pnas.91.10.4219
发表时间：
1994-05-10
影响因子：
11.1
作者：
SCHAFER, M;CARTER, L;STEIN, C
通讯作者：
STEIN, C
眼粘膜相关淋巴组织中细胞骨架抗原的表达。
影响因子：
4.4
作者：
Yen,MT;Pflugfelder,SC;Crouse,CA;Atherton,SS
通讯作者：
Atherton,SS
兔眼粘蛋白单克隆抗体的开发。
影响因子：
4.4
作者：
Huang,AJ;Tseng,SC
通讯作者：
Tseng,SC