LARP1 predict the prognosis for early-stage and AFP-normal hepatocellular carcinoma.
LARP1 predict the prognosis for early-stage and AFP-normal hepatocellular carcinoma.
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LARP1 预测早期和 AFP 正常肝细胞癌的预后
DOI：
10.1186/1479-5876-11-272
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发表时间：
2013-10-26
影响因子：
7.4
通讯作者：
Gao Z
中科院分区：
文献类型：
--
作者：
Xie C;Huang L;Xie S;Xie D;Zhang G;Wang P;Peng L;Gao Z
BackgroundThe La-related protein 1 (LARP1) has been found to be a RNA binding protein and was related to spermatogenesis, embryogenesis and cell-cycle progression. The aim of this study was to investigate the prognostic value of LARP1 in hepatocellular carcinoma (HCC).MethodsLARP1 expression was examined in 15 HCC cell lines and 272 clinical specimens using real-time PCR, immunohistochemistry (IHC) and western blot analysis (WB). LARP1 expression was also studied in 6 paired HCC lesions and the adjacent non-cancerous tissue samples. Statistical analyses were applied to derive association between LARP1 expression scores and clinical characters as well as patient survival.ResultsmRNA and protein levels of LARP1 were higher in HCC cell lines and HCC lesions than in normal liver epithelial cells and the paired adjacent noncancerous tissues. LARP1 expression was correlated to survival time, vital status, tumor size and Child-Pugh score. Overall survival analysis showed HCC patients with high LARP1 expression level had lower survival rate (P< 0.01). Importantly, this correlation remained significant in patients with early-stage HCC or with normal serum AFP level.ConclusionsLARP1 protein may represent a promising biomarker for predicting the prognosis of HCC, including in early-stage and AFP-normal patients.
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DOI：
10.1111/j.1478-3231.2008.01957.x
发表时间：
2009-04
期刊：
Liver international : official journal of the International Association for the Study of the Liver
影响因子：
--
作者：
Tandon P;Garcia-Tsao G
通讯作者：
Garcia-Tsao G
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
6.4
作者：
Peng, SY;Chen, WJ;Hsu, HC
通讯作者：
Hsu, HC
细胞增殖上调可预测肝细胞癌的不良预后，并通过下调 FOXO3a 促进肝癌发生
影响因子：
3.7
作者：
Xie C;Song LB;Wu JH;Li J;Yun JP;Lai JM;Xie DY;Lin BL;Yuan YF;Li M;Gao ZL
通讯作者：
Gao ZL
影响因子：
4.5
作者：
Bousquet-Antonelli, Cecile;Deragon, Jean-Marc
通讯作者：
Deragon, Jean-Marc