DNA repair capacity for ultraviolet light-induced damage is reduced in peripheral lymphocytes from patients with basal cell carcinoma.
DNA repair capacity for ultraviolet light-induced damage is reduced in peripheral lymphocytes from patients with basal cell carcinoma.
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基底细胞癌患者的外周淋巴细胞对紫外线引起的损伤的 DNA 修复能力降低。
DOI：
10.1111/1523-1747.ep12606207
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Grossman,L
中科院分区：
文献类型：
--
作者：
Wei,Q;Matanoski,GM;Farmer,ER;Hedayati,MA;Grossman,L
日光照射和某些宿主因素，如红色头发和白皙皮肤，是非黑色素瘤皮肤癌的既定风险因素。由于DNA修复能力不足导致了一种罕见的遗传性疾病--着色性干皮病--皮肤癌的发生，我们在最近的一项人口研究中探索了这种缺陷作为一个病因。在一项基于临床的病例对照研究中，我们使用了一种新的DNA修复方法，即宿主细胞再激活，来验证DNA修复减少是阳光诱导的基底细胞癌发生的潜在分子机制的假设。对88例原发性基底细胞癌患者和135例非肿瘤对照的外周血淋巴细胞修复报告基因氯霉素乙酰转移酶DNA损伤的能力进行了检测。所有受试者年龄在20-60岁之间，年龄(±5)岁和性别相匹配，在那些经常日光浴、晒黑能力差、有多次晒伤史、暴露于化学品或多次医学照射的人中，基底细胞癌患者的DNA修复能力显著低于对照组(p<；0.05)。红色头发和浅色皮肤(I型)的基底细胞癌患者的DNA修复能力也明显较低。与对照组相比，具有特定危险因素的基底细胞癌患者的DNA修复能力相对下降了10%-28%。这些发现提供了证据，证明DNA修复能力降低是普通人群中阳光诱发皮肤癌的潜在分子机制之一。
Sunlight exposure and certain host factors such as red hair and fair skin are established risk factors for non-melanoma skin cancers. Because deficient DNA repair capacity has contributed to the development of skin cancers in a rare genetic disease, xeroderma pigmentosum, we explored this deficiency as an etiologic factor in a recent population study. We used a new DNA repair assay, the host-cell reactivation, in a clinic-based case-control study to test the hypothesis that reduced DNA repair is the underlying molecular mechanism for the development of sunlight-induced basal cell carcinoma. The peripheral lymphocytes from 88 patients with primary BCC and 135 cancer- free controls were tested for their capacity to repair ultraviolet light-induced DNA damage in a reporter gene, chloramphenicol acetyl transferase. All subjects were between the ages of 20 and 60 years and were frequency matched by age (±5) and sex, Among those who reported frequent sunbathing, poor tanning ability, a history of multiple sunburns, exposure to chemicals, or multiple medical irradiations, the BCC patients had significantly lower DNA repair capacity than controls (p<0.05). DNA repair capacity was also found substantially lower in the basal cell carcinoma patients who had red hair and light skin (type I). Compared to controls, basal cell carcinoma cases with selected risk factors had a relative decrease in DNA repair capacity of 10-28%. These findings provided evidence that reduced DNA repair capacity is one of the underlying molecular mechanisms for sunlight-induced skin carcinogenesis in the general population.
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影响因子：
6.4
作者：
KRICKER, A;ARMSTRONG, BK;HEENAN, PJ
通讯作者：
HEENAN, PJ
影响因子：
11.2
作者：
W. F. Athas;M. Hedayati;Genevieve M. Matanoski;Evan R. Farmer;Lawrence Grossman
通讯作者：
W. F. Athas;M. Hedayati;Genevieve M. Matanoski;Evan R. Farmer;Lawrence Grossman
前瞻性女性队列中基底细胞癌的危险因素。
影响因子：
5.6
作者：
Hunter,DJ;Colditz,GA;Stampfer,MJ;Rosner,B;Willett,WC;Speizer,FE
通讯作者：
Speizer,FE
影响因子：
8.8
作者：
Silverstone, H;Searle, J H
通讯作者：
Searle, J H
着色性干皮病的癌症控制。
影响因子：
--
作者：
H. Lynch;B. Frichot;J. Lynch
通讯作者：
J. Lynch