Mosquito densonucleosis viruses cause dramatically different infection phenotypes in the C6/36 Aedes albopictus cell line.
Mosquito densonucleosis viruses cause dramatically different infection phenotypes in the C6/36 Aedes albopictus cell line.
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蚊子浓核病毒在 C6/36 白纹伊蚊细胞系中引起显着不同的感染表型。
DOI：
10.1016/j.virol.2005.04.037
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发表时间：
2005
期刊：
影响因子：
3.7
通讯作者：
Carlson,Jonathan
中科院分区：
文献类型：
--
作者：
Paterson,Andrew;Robinson,Erin;Suchman,Erica;Afanasiev,Boris;Carlson,Jonathan
Mosquito densoviruses generally establish persistent infections in mosquito cell lines including the C6/36 Aedes albopictus cell line. In contrast, the closely related Haemagogus equinus densovirus (HeDNV) causes dramatic cytopathic effects in the C6/36 Aedes albopictus cell line. Infection of C6/36 cells by HeDNV causes internucleosomal fragmentation of host chromosomal DNA, changes in cellular morphology (membrane budding, apoptotic bodies), caspase activation and exposure of phosphatidylserine on the cellular membrane. This is accompanied by a higher rate of infection and more vigorous production of virus in these cells. These observations are consistent with the induction of apoptosis during infection. In contrast, expression of AeDNV proteins in C6/36 cells does not cause obvious cytopathic effects although NS1 expression causes accumulation of cells in G2 phase. C6/36 cells persistently infected with AeDNV were not protected from superinfection with HeDNV. Thus, there does not seem to be an antiviral state induced by AeDNV persistent infection.
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DOI：
10.1016/s0006-291x(03)00631-4
发表时间：
2003
影响因子：
3.1
作者：
K. Muthumani;A. Y. Choo;D. Hwang;M. Chattergoon;Nathanael N Dayes;Donghui Zhang;Mark D. Lee;U. Duvvuri;D. Weiner
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