Optimization of touchscreen-based behavioral paradigms in mice: implications for building a battery of tasks taxing learning and memory functions.
Optimization of touchscreen-based behavioral paradigms in mice: implications for building a battery of tasks taxing learning and memory functions.
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DOI：
10.1371/journal.pone.0100817
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Marti A
中科院分区：
文献类型：
--
作者：
Delotterie D;Mathis C;Cassel JC;Dorner-Ciossek C;Marti A
虽然许多临床病理状态现在可以通过成像和生化分析来检测，但神经心理学测试通常被认为是确认诊断的有价值的补充方法，特别是对于阿尔茨海默病或帕金森病以及精神分裂症等疾病。20年前，基于触摸屏的自动测试电池被引入人类，用于评估认知功能，最近又成功地在猴子和啮齿动物身上进行了反翻译。我们重点优化了小鼠三种不同行为范式的方案：配对联想学习（PAL）和视觉-运动条件学习（VMCL）任务的两种变体。这些任务的习得在未受过训练的小鼠和未受过训练的小鼠中进行了评估。在幼稚的小鼠中，我们设法定义了测试条件，允许在上述三个任务中随着时间的推移显著改善学习表现。在预先训练的小鼠中，我们观察到特定任务组合后的不同习得率。特别是，我们发现先前在VMCL范式中训练的动物随后学习sPAL规则的能力较差。与先前的发现一起，这些数据证实了使用这种行为分析来评估小鼠不同认知功能障碍模型的可行性。他们还强调，当啮齿动物通过一系列不同的认知触屏范式时，任务之间的相互作用存在风险。
Although many clinical pathological states are now detectable using imaging and biochemical analyses, neuropsychological tests are often considered as valuable complementary approaches to confirm diagnosis, especially for disorders like Alzheimer’s or Parkinson’s disease, and schizophrenia. The touchscreen-based automated test battery, which was introduced two decades ago in humans to assess cognitive functions, has recently been successfully back-translated in monkeys and rodents. We focused on optimizing the protocol of three distinct behavioral paradigms in mice: two variants of the Paired Associates Learning (PAL) and the Visuo-Motor Conditional Learning (VMCL) tasks. Acquisition of these tasks was assessed in naive versus pre-trained mice. In naive mice, we managed to define testing conditions allowing significant improvements of learning performances over time in the three aforementioned tasks. In pre-trained mice, we observed differential acquisition rates after specific task combinations. Particularly, we identified that animals previously trained in the VMCL paradigm subsequently poorly learned the sPAL rule. Together with previous findings, these data confirm the feasibility of using such behavioral assays to evaluate the power of different models of cognitive dysfunction in mice. They also highlight the risk of interactions between tasks when rodents are run through a battery of different cognitive touchscreen paradigms.
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影响因子：
4.7
作者：
Bussey TJ;Holmes A;Lyon L;Mar AC;McAllister KA;Nithianantharajah J;Oomen CA;Saksida LM
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
2
作者：
Bussey, Timothy J.;Padain, Tina L.;Saksida, Lisa M.
通讯作者：
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影响因子：
3.4
作者：
Chudasama, Y;Bussey, TJ;Muir, JL
通讯作者：
Muir, JL
DOI：
10.1097/wnn.0b013e318190cf75
发表时间：
2008-12
期刊：
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
影响因子：
--
作者：
Knopman DS
通讯作者：
Knopman DS