Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival.
Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival.
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DOI：
10.1186/1471-2407-9-176
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发表时间：
2009-06-09
期刊：
影响因子：
3.8
通讯作者：
He J
中科院分区：
文献类型：
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作者：
Xiang ZL;Zeng ZC;Tang ZY;Fan J;Zhuang PY;Liang Y;Tan YS;He J
趋化因子和骨髓归巢受体CXCR 4与各种癌症的转移有关。本研究旨在分析CXCR 4表达与肝细胞癌（HCC）骨转移和患者生存的关系。使用组织微阵列对来自具有（n = 43）和不具有（n = 138）骨转移的HCC患者的肿瘤组织进行CXCR 4的免疫组织化学染色。半定量评价免疫反应性。采用基于受试者操作特征的方法和逻辑回归分析来确定临床病理因素（包括CXCR 4表达）在骨转移中的预测价值。通过Kaplan-Meier曲线和对数秩检验分析患者生存率。CXCR 4在43例骨转移患者中有34例（79.1%）过度表达，在138例无骨转移患者中有57例（41.3%）过度表达。CXCR 4表达与HCC骨转移相关（相关系数：0.551，P < 0.001），并可预测HCC骨转移（AUC：0.689，95%CI：0.601 - 0.776，P < 0.001）。CXCR 4染色强度与无骨转移生存期相关（相关系数：-0.359; P = 0.018）。原发性肿瘤中CXCR 4过表达（n = 91）降低了总中位生存期（18.0个月vs.36.0个月，P <0.001）。多变量分析确定CXCR 4是无病生存期（相对风险[RR]：5.440; P = 0.023）和总生存期（RR：7.082; P = 0.001）降低的一个强有力的独立风险因素。CXCR 4在原发性HCC中的表达可能是骨转移的独立危险因素，并可能与不良临床结局相关。
The chemokine and bone marrow-homing receptor CXCR4 is implicated in metastases of various cancers. This study was conducted to analyze the association of CXCR4 expression with hepatocellular carcinoma (HCC) bone metastasis and patient survival. Tumor tissue from HCC patients with (n = 43) and without (n = 138) bone metastasis was subjected to immunohistochemical staining for CXCR4 using tissue microarrays. Immunoreactivity was evaluated semi-quantitatively. A receiver-operating characteristic-based approach and logistical regression analysis were used to determine the predictive value of clinicopathologic factors, including CXCR4 expression, in bone metastasis. Patient survival was analyzed by Kaplan-Meier curves and log-rank tests. CXCR4 overexpression was detected in 34 of 43 (79.1%) patients with bone metastases and in 57 of 138 (41.3%) without bone metastases. CXCR4 expression correlated with (correlation coefficient: 0.551, P < 0.001) and was predictive of HCC bone metastases (AUC: 0.689; 95%CI: 0.601 – 0.776; P < 0.001). CXCR4 staining intensity correlated with the bone metastasis-free survival (correlation coefficient: -0.359; P = 0.018). CXCR4 overexpression in primary tumors (n = 91) decreased overall median survival (18.0 months vs. 36.0 months, P <0.001). Multivariable analysis identified CXCR4 as a strong, independent risk factor for reduced disease-free survival (relative risk [RR]: 5.440; P = 0.023) and overall survival (RR: 7.082; P = 0.001). CXCR4 expression in primary HCCs may be an independent risk factor for bone metastasis and may be associated with poor clinical outcome.
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DOI：
10.1016/j.bbrc.2006.05.110
发表时间：
2006-07-21
影响因子：
3.1
作者：
Shim, Hyunsuk;Lau, Stephen K.;Liang, Zhongxing
通讯作者：
Liang, Zhongxing
高度恶性的人神经胶质瘤优先表达趋化因子受体CXCR4及其与患者生存率低的关系
影响因子：
4.8
作者：
Bian, Xiu-Wu;Yang, Shi-Xin;Wang, Ji Ming
通讯作者：
Wang, Ji Ming
影响因子：
82.9
作者：
Kononen, J;Bubendorf, L;Kallioniemi, OP
通讯作者：
Kallioniemi, OP
影响因子：
4.8
作者：
Zhang, Libo;Yegery, Herman;Baruchel, Sylvain
通讯作者：
Baruchel, Sylvain
影响因子：
8.8
作者：
通讯作者：
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