Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma.
Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma.
复制标题
DOI：
10.3389/fnins.2023.1150694
复制
发表时间：
2023
影响因子：
4.3
通讯作者：
Zheng, James Q.
中科院分区：
文献类型：
--
作者：
Ye, Changtian;Behnke, Joseph A.;Hardin, Katherine R.;Zheng, James Q.
头部反复受到物理损伤，包括那些导致轻度创伤性脑损伤（mTBI）的情况，是多种神经退行性疾病的已知风险因素，这些疾病包括阿尔茨海默病（AD）、帕金森病（PD）和慢性创伤性脑病（CTE）。尽管大多数遭受mTBI的人通常在几周内似乎能完全康复，但有一部分人在晚年出现迟发性症状。由于大多数mTBI研究都集中在损伤的急性期，对于早期轻度头部创伤后在晚年出现神经退行性变的相关机制了解并不全面。最近采用的基于果蝇的脑损伤模型相较于现有的临床前动物模型具有一些独特优势，包括一个易于处理的框架，适用于高通量检测，以及相对较短的寿命有利于进行终身机制研究。使用果蝇还提供了一个研究与神经退行性疾病相关的重要风险因素的机会，特别是年龄和性别。在这篇综述中，我们综述了当前的文献，这些文献研究了年龄和性别作为人类和临床前模型（包括哺乳动物和果蝇模型）中头部创伤介导的神经退行性变的促成因素。我们讨论了人类和果蝇在衰老、性别差异和病理生理学方面的相似性和差异。最后，我们强调果蝇是一种有效的工具，可用于研究头部创伤诱导的神经退行性变的潜在机制以及确定治疗和康复的治疗靶点。
Repetitive physical insults to the head, including those that elicit mild traumatic brain injury (mTBI), are a known risk factor for a variety of neurodegenerative conditions including Alzheimer’s disease (AD), Parkinson’s disease (PD), and chronic traumatic encephalopathy (CTE). Although most individuals who sustain mTBI typically achieve a seemingly full recovery within a few weeks, a subset experience delayed-onset symptoms later in life. As most mTBI research has focused on the acute phase of injury, there is an incomplete understanding of mechanisms related to the late-life emergence of neurodegeneration after early exposure to mild head trauma. The recent adoption of Drosophila-based brain injury models provides several unique advantages over existing preclinical animal models, including a tractable framework amenable to high-throughput assays and short relative lifespan conducive to lifelong mechanistic investigation. The use of flies also provides an opportunity to investigate important risk factors associated with neurodegenerative conditions, specifically age and sex. In this review, we survey current literature that examines age and sex as contributing factors to head trauma-mediated neurodegeneration in humans and preclinical models, including mammalian and Drosophila models. We discuss similarities and disparities between human and fly in aging, sex differences, and pathophysiology. Finally, we highlight Drosophila as an effective tool for investigating mechanisms underlying head trauma-induced neurodegeneration and for identifying therapeutic targets for treatment and recovery.
登录
查看更多内容
影响因子：
4.5
作者：
Ameku T;Niwa R
通讯作者：
Niwa R
DOI：
10.1016/j.nicl.2020.102534
发表时间：
2021
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bittencourt-Villalpando M;van der Horn HJ;Maurits NM;van der Naalt J
通讯作者：
van der Naalt J
影响因子：
4.6
作者：
Barekat A;Gonzalez A;Mauntz RE;Kotzebue RW;Molina B;El-Mecharrafie N;Conner CJ;Garza S;Melkani GC;Joiner WJ;Lipinski MM;Finley KD;Ratliff EP
通讯作者：
Ratliff EP
影响因子：
2.3
作者：
Berz, Kate;Divine, Jon;Myer, Gregory D.
通讯作者：
Myer, Gregory D.
影响因子：
9.2
作者：
Brogiolo, W;Stocker, H;Hafen, E
通讯作者：
Hafen, E