Finding sequences for over 270 orphan enzymes.
Finding sequences for over 270 orphan enzymes.
复制标题
查找超过270个孤儿酶的序列。
DOI：
10.1371/journal.pone.0097250
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Rhee CD
中科院分区：
文献类型：
--
作者：
Shearer AG;Altman T;Rhee CD
尽管在测序技术方面取得了进步，但仍有大量特征的酶活性，没有已知的相关序列。编码序列。我们通过数据库搜索和文献审查的组合报告了一种解决孤儿的方法。重新连接了270个孤儿酶与相应的序列。
Despite advances in sequencing technology, there are still significant numbers of well-characterized enzymatic activities for which there are no known associated sequences. These ‘orphan enzymes’ represent glaring holes in our biological understanding, and it is a top priority to reunite them with their coding sequences. Here we report a methodology for resolving orphan enzymes through a combination of database search and literature review. Using this method we were able to reconnect over 270 orphan enzymes with their corresponding sequence. This success points toward how we can systematically eliminate the remaining orphan enzymes and prevent the introduction of future orphan enzymes.
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DOI：
10.1007/978-1-60761-977-2_2
发表时间：
2011-01-01
期刊：
BIOINFORMATICS FOR COMPARATIVE PROTEOMICS
影响因子：
--
作者：
O'Donovan, Claire;Apweiler, Rolf
通讯作者：
Apweiler, Rolf
影响因子：
12.3
作者：
Chen L;Vitkup D
通讯作者：
Vitkup D
影响因子：
14.9
作者：
Harris, MA;Clark, J;White, R
通讯作者：
White, R
影响因子：
4.1
作者：
BEEDLE, AS;REES, HH;GOODWIN, TW
通讯作者：
GOODWIN, TW
影响因子：
5.4
作者：
Koivistoinen, Outi M.;Hilditch, Satu;Richard, Peter
通讯作者：
Richard, Peter