A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote.
A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote.
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DOI：
10.1371/journal.pgen.1007836
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发表时间：
2018-11
期刊：
影响因子：
4.5
通讯作者：
Zanders SE
中科院分区：
文献类型：
--
作者：
Bravo Núñez MA;Lange JJ;Zanders SE
减数分裂驱动基因是一种自私的等位基因，可以破坏配子发生，增加向后代的传递。驱动程序强加了适应成本，给基因组带来了进化抑制子的压力。在这里，我们研究了来自裂殖酵母的wtf基因家族，以前在野生分离株中被证明含有减数分裂驱动因素。我们发现，在实验室种群中发现的wtf13是减数分裂的驱动因素。Wtf13通过产生一种可扩散的毒物和一种孢子特有的解毒剂来杀死不继承它的孢子。此外，我们证明wtf13被另一个wtf基因wtf18-2抑制，wtf18-2是实验室自发产生的，只产生解毒剂。WTF18-2不会不加区别地防止孢子破坏。相反，它只拯救继承wtf18-2的孢子。通过这种方式，wtf18-2自私地获得了其自身的传输优势，同时抑制了wtf13的驱动。这为减数分裂驱动抑制因子建立了一个新的范式，并为驱动系统的机制和进化提供了洞察力。杀手减数分裂驱动基因是自私的基因，通过破坏不继承它们的配子(例如精子)而导致不育。这使得它们可以被传播到多达100%的幸存配子中。由于这些减数分裂杀手给生物体带来了巨大的适应成本，动力的抑制者预计会进化出来。我们和其他人最近发现，在自然分离的分裂酵母中，wtf基因家族的成员是减数分裂的杀手。这些基因产生一种毒药来杀死配子，但用解毒剂拯救那些继承了司机的人。在这项工作中，我们发现在深入研究的实验室菌株中发现的另一个wtf基因wtf13也是减数分裂的驱动因素。这个司机只有在缺少另一个wtf基因wtf18-2的情况下才能驾驶，wtf18-2通过模仿wtf13的解毒剂发挥作用。通过只保护继承该基因的孢子，wtf18-2自私地获得了自己的传播优势，为驱动抑制因子建立了一种新的范例。
Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve suppressors. Here we investigate the wtf gene family from Schizosaccharomyces pombe, previously shown to contain meiotic drivers in wild isolates. We discovered that wtf13 found in lab stocks is a meiotic driver. wtf13 kills spores that do not inherit it by generating both a diffusible poison and a spore-specific antidote. Additionally, we demonstrate that wtf13 is suppressed by another wtf gene, wtf18-2, that arose spontaneously in the lab and makes only an antidote. Wtf18-2 does not act indiscriminately to prevent spore destruction. Instead, it rescues only the spores that inherit wtf18-2. In this way, wtf18-2 selfishly gains a transmission advantage of its own while dampening the drive of wtf13. This establishes a novel paradigm for meiotic drive suppressors and provides insight into the mechanisms and evolution of drive systems. Killer meiotic drivers are selfish genes that cause infertility by destroying the gametes (e.g. sperm) that do not inherit them. This allows them to be transmitted into up to 100% of the surviving gametes. Because of the significant fitness cost that these killer meiotic drivers impose to the organism, suppressors of drive are expected to evolve. We and others recently discovered that members of the wtf gene family in natural isolates of fission yeast are killer meiotic drivers. These genes generate a poison to kill gametes, but rescue those that inherit the driver with an antidote. In this work, we discovered that an additional wtf gene, wtf13 found in intensely studied lab strains is also a meiotic driver. This driver is only capable of driving in the absence of another wtf gene, wtf18-2, which works by mimicking the antidote of wtf13. By protecting only the spores that inherit the gene, wtf18-2 selfishly gains a transmission advantage of its own, establishing a novel paradigm for drive suppressors.
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影响因子：
7
作者：
Bowen, NJ;Jordan, IK;Levin, HL
通讯作者：
Levin, HL
DOI：
10.1083/jcb.201307043
发表时间：
2014-02-17
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chen J;Smoyer CJ;Slaughter BD;Unruh JR;Jaspersen SL
通讯作者：
Jaspersen SL
影响因子：
64.5
作者：
Dawe, R. Kelly;Lowry, Elizabeth G.;Hiatt, Evelyn N.
通讯作者：
Hiatt, Evelyn N.
精神分裂症的基因组和表型多样性。
影响因子：
30.8
作者：
Jeffares DC;Rallis C;Rieux A;Speed D;Převorovský M;Mourier T;Marsellach FX;Iqbal Z;Lau W;Cheng TM;Pracana R;Mülleder M;Lawson JL;Chessel A;Bala S;Hellenthal G;O'Fallon B;Keane T;Simpson JT;Bischof L;Tomiczek B;Bitton DA;Sideri T;Codlin S;Hellberg JE;van Trigt L;Jeffery L;Li JJ;Atkinson S;Thodberg M;Febrer M;McLay K;Drou N;Brown W;Hayles J;Carazo Salas RE;Ralser M;Maniatis N;Balding DJ;Balloux F;Durbin R;Bähler J
通讯作者：
Bähler J
DOI：
10.1126/science.aan0092
发表时间：
2017-11-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Akera T;Chmátal L;Trimm E;Yang K;Aonbangkhen C;Chenoweth DM;Janke C;Schultz RM;Lampson MA
通讯作者：
Lampson MA