Upregulation of RECQL4 expression predicts poor prognosis in hepatocellular carcinoma.
Upregulation of RECQL4 expression predicts poor prognosis in hepatocellular carcinoma.
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RECQL4表达上调预示肝细胞癌预后不良
DOI：
10.3892/ol.2018.7860
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发表时间：
2018-04
期刊：
影响因子：
2.9
通讯作者：
Liao W
中科院分区：
文献类型：
--
作者：
Li J;Jin J;Liao M;Dang W;Chen X;Wu Y;Liao W
先前的cDNA微阵列实验显示，ATP依赖性DNA解旋酶Q4（RECQL 4）基因在肝细胞癌（HCC）组织中过表达。然而，RECQL 4在HCC中的确切作用仍然未知。本研究旨在研究RECQL 4在HCC中的表达，并分析RECQL 4在HCC患者中表达的潜在临床意义。通过逆转录-定量聚合酶链反应评估了205份肝癌组织样本中RECQL 4 mRNA的表达。结果表明，RECQL 4 mRNA在肝癌组织中的表达明显高于癌旁正常肝组织（P<0.001）。RECQL 4 mRNA表达水平与高AFP水平（>100 ng/ml）、肿瘤大小（>6 cm）和巴塞罗那临床肝癌分期相关（均P<0.05）。Kaplan-Meier生存分析显示RECQL 4表达水平高的HCC患者与表达水平低的患者相比，无病生存期（DFS）和总生存期（OS）时间显著缩短。多变量生存分析显示RECQL 4高表达是HCC患者DFS [HR，1.635; 95% CI，1.062-2.515; P=0.025]和OS [HR，1.618; 95% CI，1.050-2.493; P=0.029]的显著独立预测因子。这些数据表明RECQL 4可能是HCC患者诊断和预后的新生物标志物。
Previous cDNA microarray experiments revealed that the ATP-dependent DNA helicase Q4 (RECQL4) gene is overexpressed in hepatocellular carcinoma (HCC) tissues. However, the exact role of RECQL4 in HCC remains unknown. The present study aimed to investigate RECQL4 expression in HCC and to analyze the potential clinical implications of RECQL4 expression in HCC patients. The expression of RECQL4 mRNA was assessed in 205 samples of HCC tissues by reverse transcription-quantitative polymerase chain reaction. The results demonstrated that the expression of RECQL4 mRNA in HCC tissues was significantly higher compared with adjacent normal liver tissues (P<0.001). The level of RECQL4 mRNA expression was associated with high a-fetoprotein (AFP) levels (>100 ng/ml), tumor size (>6 cm), and Barcelona Clinic Liver Cancer stage (all P<0.05). Kaplan-Meier survival analysis indicated that HCC patients with higher levels of RECQL4 expression exhibited significantly shorter disease-free survival (DFS) and overall survival (OS) times compared with those with low levels of expression. Multivariate survival analysis revealed that high RECQL4 expression was a significant independent predictor for DFS [HR, 1.635; 95% confidence interval (CI), 1.062–2.515; P=0.025] and OS (HR, 1.618; 95% CI, 1.050–2.493; P=0.029) of HCC patients. These data indicated that RECQL4 might be a novel diagnostic and prognostic biomarker for HCC patients.
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