Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism.
Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism.
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DOI：
10.1016/j.physbeh.2012.04.010
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发表时间：
2012-12-05
影响因子：
2.9
通讯作者：
Blanchard, Robert J.
中科院分区：
文献类型：
--
作者：
Corley, Michael J.;Meyza, Ksenia Z.;Blanchard, D. Caroline;Blanchard, Robert J.
临床研究表明，被诊断患有自闭症的儿童表现出异常的硫酸盐化学，这对细胞和代谢过程至关重要。为了确定近交系BTBR T+tf/J小鼠是否在硫酸盐化学中显示自闭症相关畸变，本研究检查了BTBR T+tf/J、近交系C57 BL/6 J和远交系CD-1小鼠的血浆硫酸盐浓度。结果显示，与C57 BL/6 J和CD-1小鼠相比，BTBR T+tf/J小鼠表现出显著更低的血浆硫酸盐浓度。这些结果表明，BTBR小鼠表现出自闭症相关的异常硫酸盐化学和硫酸盐依赖性系统的作用，与自闭症相关的行为畸变检查可能会提供额外的效用。
Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, the present study examined plasma sulfate concentrations in BTBR T+tf/J, inbred C57BL/6J, and outbred CD-1 mice. Results showed that the BTBR T+tf/J mouse exhibits significantly lower plasma sulfate concentrations in comparison to both C57BL/6J and CD-1 mice. These results suggest that the BTBR mouse shows autism-relevant abnormalities in sulfate chemistry and may serve additional utility in examining the role of sulfate and sulfate-dependent systems in relation to autism-relevant behavioral aberrations.
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影响因子：
3.7
作者：
Heo Y;Zhang Y;Gao D;Miller VM;Lawrence DA
通讯作者：
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影响因子：
10.5
作者：
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DOI：
10.1073/pnas.2231298100
发表时间：
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作者：
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