Aberrant immune responses in a mouse with behavioral disorders.
Aberrant immune responses in a mouse with behavioral disorders.
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DOI：
10.1371/journal.pone.0020912
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Lawrence DA
中科院分区：
文献类型：
--
作者：
Heo Y;Zhang Y;Gao D;Miller VM;Lawrence DA
最近有报道称，BTBR T+tf/J（BTBR）小鼠的行为类似于自闭症个体的行为，因为这种品系在社会互动中有障碍，并且行为的重复和刻板模式受到限制。由于免疫反应，包括自身免疫反应，已知会影响行为，自闭症个体具有异常的免疫活动，我们评估了BTBR小鼠的免疫系统，并将其免疫力和神经炎症程度与C57 BL/6（B6）小鼠（一种高度社会控制品系）和F1后代进行了比较。在出生后第21天和出生后第70天进行行为分析后对小鼠进行评估。与B6小鼠相比，BTBR小鼠的血清IgG和IgE、IgG抗脑抗体（Abs）以及脑中沉积的IgG和IgE的量显著更高，脑中细胞因子（尤其是IL-33、IL-18和IL-1β）的表达升高，表达MHC II类的小胶质细胞的比例增加。F1小鼠具有中等水平的抗体和细胞因子以及社会活动。BTBR小鼠的高Ab水平与其增加的CD 40 hi/I-Ahi B细胞和IgG分泌型B细胞数量一致。在用KLH免疫后，BTBR小鼠产生比B6小鼠多2-3倍的抗KLH Ab。与体液免疫相反，BTBR小鼠比B6或BALB/c小鼠明显更容易患上衣原体病。BTBR小鼠的Th 2样免疫特征和它们的组成性神经炎症表明，自身免疫特征与它们的异常行为有关，正如一些患有自闭症的人所建议的那样。
BTBR T+tf/J (BTBR) mice have recently been reported to have behaviors that resemble those of autistic individuals, in that this strain has impairments in social interactions and a restricted repetitive and stereotyped pattern of behaviors. Since immune responses, including autoimmune responses, are known to affect behavior, and individuals with autism have aberrant immune activities, we evaluated the immune system of BTBR mice, and compared their immunity and degree of neuroinflammation with that of C57BL/6 (B6) mice, a highly social control strain, and with F1 offspring. Mice were assessed at postnatal day (pnd) 21 and after behavioral analysis at pnd70. BTBR mice had significantly higher amounts of serum IgG and IgE, of IgG anti-brain antibodies (Abs), and of IgG and IgE deposited in the brain, elevated expression of cytokines, especially IL-33 IL-18, and IL-1β in the brain, and an increased proportion of MHC class II-expressing microglia compared to B6 mice. The F1 mice had intermediate levels of Abs and cytokines as well as social activity. The high Ab levels of BTBR mice are in agreement with their increased numbers of CD40hi/I-Ahi B cells and IgG-secreting B cells. Upon immunization with KLH, the BTBR mice produced 2–3 times more anti-KLH Abs than B6 mice. In contrast to humoral immunity, BTBR mice are significantly more susceptible to listeriosis than B6 or BALB/c mice. The Th2-like immune profile of the BTBR mice and their constitutive neuroinflammation suggests that an autoimmune profile is implicated in their aberrant behaviors, as has been suggested for some humans with autism.
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影响因子：
3.3
作者：
Cao, L;Lawrence, DA
通讯作者：
Lawrence, DA
影响因子：
5.7
作者：
Alexander, Andrew L.;Lee, Jee Eun;Lainhart, Janet E.
通讯作者：
Lainhart, Janet E.
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM
DOI：
10.1196/annals.1381.010
发表时间：
2007-01-01
期刊：
AUTOIMMUNITY, PT C
影响因子：
--
作者：
Cabanlit, Maricel;Wills, Sharifia;de Water, Judy Van
通讯作者：
de Water, Judy Van
影响因子：
5.5
作者：
Hafezi-Moghadam, Ali;Thomas, Kennard L.;Wagner, Denisa D.
通讯作者：
Wagner, Denisa D.