A review on the food digestion in the digestive tract and the used in vitro models.
A review on the food digestion in the digestive tract and the used in vitro models.
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DOI：
10.1016/j.crfs.2021.04.004
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发表时间：
2021
影响因子：
6.3
通讯作者：
Sensoy I
中科院分区：
文献类型：
--
作者：
Sensoy I
在模型系统中复制或模拟人类消化系统条件以获得尽可能准确的食物消化相关数据至关重要。因此，所获得的数据可有助于健康与营养关系等研究。本文综述了人体消化系统在食物消化过程中的作用，并比较了各种模型的模拟能力，特别是动态体外模型。讨论了人体消化系统对食物消化的调控作用及食物基质在消化系统中的分解机理。动态体外模型及其与人体消化系统的相关性进行了描述。讨论了近20年来人工神经网络的研究进展，指出了人工神经网络的局限性，展望了人工神经网络的发展前景。对这些模型的广泛使用和改进将扩展我们对食物基质和消化系统复杂相互作用的了解。因此，有可能设计出具有更好健康益处的下一代食品。消化是一个多功能和多规模的物理化学过程的组合。食物的组成、结构和加工过程影响食物的消化。在食物消化研究中有许多动态体外模型。模型的结果应谨慎解释。
It is crucial to replicate or mimic the human digestive system conditions closely in model systems to have the food digestion-related data as accurate as possible. Thus, the data obtained could contribute to studies like those on the relationship between health and nutrition. This review aims to express the human digestion system’s role in food digestion and compare the capability of the models used in simulations, especially the dynamic in vitro models. Activities of the human digestive system governing food digestion and the food matrix’s disintegration mechanism in the digestive system were discussed. Dynamic in vitro models and their relevance to the human digestive system were described. Advancements in the last 20 years, as well as limitations of those artificial systems, with prospects, were discussed. Extensive use and improvement on these models will extend our knowledge of the food matrix and digestive system’s complex interaction. Thus, it will be possible to design next-generation foods with improved health benefits. Digestion is a combination of versatile and multiple scales physicochemical processes. Food composition, structure, and processing affect food digestion. There are many dynamic in vitro models used in food digestion studies. Results from the models should be interpreted with care.
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