Systems immunology: just getting started.

Systems immunology: just getting started.
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DOI:
10.1038/ni.3768
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发表时间:
2017-06-20
期刊:
影响因子:
30.5
通讯作者:
Furman D
Furman D
中科院分区:
医学1区
文献类型:
--
作者:
Davis MM;Tato CM;Furman D

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免疫学中的系统生物学方法有多种形式,但在这里,我们回顾了测量广泛的免疫功能的策略,作为一种发现以前未知的关系和现象的手段,以及作为了解整个免疫系统的一种有效方式。这种方法重振了疫苗开发领域,并激发了人们的希望,即将找到新的方法来抗击已被证明对传统方法无效的传染病。系统免疫学还为直接了解人类免疫提供了一种重要的新策略,它利用了人类免疫系统可以被操纵的许多方式。
Systems-biology approaches in immunology take various forms, but here we review strategies for measuring a broad swath of immunological functions as a means of discovering previously unknown relationships and phenomena and as a powerful way of understanding the immune system as a whole. This approach has rejuvenated the field of vaccine development and has fostered hope that new ways will be found to combat infectious diseases that have proven refractory to classical approaches. Systems immunology also presents an important new strategy for understanding human immunity directly, taking advantage of the many ways the immune system of humans can be manipulated.
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