Microfluidic automation using elastomeric valves and droplets: reducing reliance on external controllers.

Microfluidic automation using elastomeric valves and droplets: reducing reliance on external controllers.
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DOI:
10.1002/smll.201200456
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发表时间:
2012-10-08
期刊:
影响因子:
13.3
通讯作者:
Takayama, Shuichi
Takayama, Shuichi
中科院分区:
材料科学1区
文献类型:
--
作者:
Kim, Sung-Jin;Lai, David;Park, Joong Yull;Yokokawa, Ryuji;Takayama, Shuichi

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This paper gives an overview of elastomeric valve- and droplet-based microfluidic systems designed to minimize the need of external pressure to control fluid flow. This concept article introduces the working principle of representative components in these devices along with relevant biochemical applications. This is followed by providing a perspective on the roles of different microfluidic valves and systems through comparison of their similarities and differences with transistors (valves) and systems in microelectronics. Despite some physical limitation of drawing analogies from electronic circuits, automated microfluidic circuit design can gain insights from electronic circuits to minimize external control units, while implementing high complexity and throughput analysis.
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