Effects of nerve growth factor on differentiation of muscle spindles following nerve lesion in neonatal rats
Effects of nerve growth factor on differentiation of muscle spindles following nerve lesion in neonatal rats
复制标题
神经生长因子对新生大鼠神经损伤后肌梭分化的影响
作者：
S. Sekiya;S. Homma;Y. Miyata;M. Kuno
Ia组感觉纤维的中枢突触功能已被证明通过每天应用NGF在新生大鼠中增强。在外周，已知Ia组感觉纤维触发肌梭的分化。在本研究中，我们研究了，在新生大鼠中，每天的神经生长因子治疗是否会影响神经被压碎的肌肉中形成的纺锤体的数量或结构。结果表明，神经夹伤后25-35 d，经神经生长因子处理后，暂时失神经支配的肌肉中重新形成了额外的梭。对侧完整侧相应肌肉中的纺锤体数量不受NGF治疗的影响。单独神经挤压后，肌肉中纺锤体的平均数量与正常值没有显著差异。这表明，用神经生长因子治疗新生大鼠可能有利于再生Ia组感觉纤维，这反过来又有助于从头纺锤体的形成作为与肌管相互作用的结果的过度外周侧支的生长。
Central synaptic function of Group Ia sensory fibers has been shown to be enhanced by daily applications of NGF in neonatal rats. In the periphery, Group Ia sensory fibers are known to trigger the differentiation of muscle spindles. In the present study we examined, in neonatal rats, whether daily NGF treatment affects the number or structure of spindles formed in muscle whose nerve has been crushed. The results show that 25–35 d after nerve crush, de novo supernumerary spindles were formed by treatment with NGF in the temporarily denervated muscle. The number of spindles in the corresponding muscle on the contralateral, intact side was not affected by NGF treatment. Following nerve crush alone, the mean number of spindles in the muscle was not significantly different from the normal value. It is suggested that treatment of neonatal rats with NGF may facilitate the outgrowth of excessive peripheral collaterals of regenerating Group Ia sensory fibers, which, in turn, contributes to the formation of de novo spindles as a result of interaction with myotubes.
DOI：
10.1002/aja.1002020307
发表时间：
1995
期刊：
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子：
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作者：
Maier,A;Mayne,R
通讯作者：
Mayne,R