Crosstalk Between Autophagy and Inflammation in Chronic Cerebral Ischaemia.
Crosstalk Between Autophagy and Inflammation in Chronic Cerebral Ischaemia.
复制标题
慢性脑缺血中自噬和炎症之间的串扰。
DOI：
10.1007/s10571-023-01336-6
复制
发表时间：
2023-08
影响因子：
4
通讯作者：
Huang, Zhi-hua
中科院分区：
文献类型：
--
作者：
Zhou, Hai-qian;Zhang, Li-mei;Li, Xiao;Huang, Zhi-hua
慢性脑缺血（CCI）是临床上常见的一种高发病率的心脑血管疾病。虽然许多发病机制已被探索，但神经科学家对CCI的发病机制仍存在很大争议。因此，阐明CCI发生、发展的机制对缺血性脑血管病的防治具有重要意义。自噬和炎症在CCI中起着至关重要的作用，但这两个过程在这种疾病中的关系仍然未知。在这里，我们回顾了进展，并讨论了CCI中自噬和炎症的功能，作用和途径，包括通过缺血修复机制从急性疾病向CCI过渡的全面观点。本文对CCI的研究和治疗提供参考。CCI中自噬和炎症之间相互作用的示意图。CCI会导致严重的、危及生命的并发症。本文综述了自噬和炎症在CCI发病机制中的作用。简而言之，可能的交点如图所示。CCI，慢性脑缺血; ER应激，内质网应激; ROS，活性氧。
Chronic cerebral ischaemia (CCI) is a high-incidence cardiovascular and cerebrovascular disease that is very common in clinical practice. Although many pathogenic mechanisms have been explored, there is still great controversy among neuroscientists regarding the pathogenesis of CCI. Therefore, it is important to elucidate the mechanisms of CCI occurrence and progression for the prevention and treatment of ischaemic cerebrovascular disorders. Autophagy and inflammation play vital roles in CCI, but the relationship between these two processes in this disease remains unknown. Here, we review the progression and discuss the functions, actions and pathways of autophagy and inflammation in CCI, including a comprehensive view of the transition from acute disease to CCI through ischaemic repair mechanisms. This review may provide a reference for future research and treatment of CCI. Schematic diagram of the interplay between autophagy and inflammation in CCI. CCI lead to serious, life-threatening complications. This review summarizes two factors in CCI, including autophagy and inflammation, which have been focused for the mechanisms of CCI. In short, the possible points of intersection are shown in the illustration. CCI, Chronic cerebral ischaemia; ER stress, Endoplasmic reticulum stress; ROS, Reactive oxygen species.
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影响因子：
5.4
作者：
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通讯作者：
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10.1016/j.jstrokecerebrovasdis.2020.104646
发表时间：
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影响因子：
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