Multigenerational epigenetic inheritance: Transmitting information across generations.
Multigenerational epigenetic inheritance: Transmitting information across generations.
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DOI：
10.1016/j.semcdb.2021.08.006
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发表时间：
2022-07
影响因子：
7.3
通讯作者：
Greer EL
中科院分区：
文献类型：
--
作者：
Burton NO;Greer EL
已观察到遗传的表观遗传信息调节各种复杂的生物体表型跨越不同的生命类群。这一不断扩大的文献表明，表观遗传在遗传中起着重要的，潜在的基础性作用。尽管这些类型的效应在生物学中扮演着重要的角色，但这种非遗传信息传递的分子介质现在才开始被破译。在这里，我们提供了一个知识框架来解释这些发现以及它们如何相互作用。我们还定义了不同类型的机制，已被发现介导表观遗传和调节表观遗传信息是否持续一代或多代。表观遗传学正在进入一个令人兴奋的阶段，在这一阶段，人们对非遗传信息如何被后代传递和破译以保持必要的环境信息而不永久改变遗传密码的机制有了更深入的了解。对表观遗传如何以及何时发生的更完整的理解将促进我们对生物学许多不同方面的理解，从生物体如何应对不断变化的环境到受父母环境影响的人类病理学。
Inherited epigenetic information has been observed to regulate a variety of complex organismal phenotypes across diverse taxa of life. This continually expanding body of literature suggests that epigenetic inheritance plays a significant, and potentially fundamental, role in inheritance. Despite the important role these types of effects play in biology, the molecular mediators of this non-genetic transmission of information are just now beginning to be deciphered. Here we provide an intellectual framework for interpreting these findings and how they can interact with each other. We also define the different types of mechanisms that have been found to mediate epigenetic inheritance and to regulate whether epigenetic information persists for one or many generations. Epigenetic inheritance is entering an exciting phase, where mechanistic understanding of how non-genetic information is transmitted and deciphered by subsequent generations to maintain essential environmental information without permanently altering the genetic code. A more complete understanding of how and when epigenetic inheritance occurs will advance our understanding of numerous different aspects of biology ranging from how organisms cope with changing environments to human pathologies influenced by a parent’s environment.
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影响因子：
64.5
作者：
Ashe A;Sapetschnig A;Weick EM;Mitchell J;Bagijn MP;Cording AC;Doebley AL;Goldstein LD;Lehrbach NJ;Le Pen J;Pintacuda G;Sakaguchi A;Sarkies P;Ahmed S;Miska EA
通讯作者：
Miska EA
影响因子：
64.5
作者：
Carone BR;Fauquier L;Habib N;Shea JM;Hart CE;Li R;Bock C;Li C;Gu H;Zamore PD;Meissner A;Weng Z;Hofmann HA;Friedman N;Rando OJ
通讯作者：
Rando OJ
影响因子：
64.5
作者：
Calarco JP;Borges F;Donoghue MT;Van Ex F;Jullien PE;Lopes T;Gardner R;Berger F;Feijó JA;Becker JD;Martienssen RA
通讯作者：
Martienssen RA
DOI：
10.1073/pnas.1113310108
发表时间：
2011-12-06
影响因子：
11.1
作者：
Burton, Nick O.;Burkhart, Kirk B.;Kennedy, Scott
通讯作者：
Kennedy, Scott
影响因子：
7.7
作者：
Bozler, Julianna;Kacsoh, Balint Z.;Bosco, Giovanni
通讯作者：
Bosco, Giovanni