Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension.
Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension.
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DOI：
10.1371/journal.pone.0012461
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发表时间：
2010-08-27
期刊：
影响因子：
3.7
通讯作者：
Domínguez H
中科院分区：
文献类型：
--
作者：
Christiansen B;Bellostas Muguerza N;Petersen AM;Kveiborg B;Madsen CR;Thomas H;Ihlemann N;Sørensen JC;Køber L;Sørensen H;Torp-Pedersen C;Domínguez H
摄入硫代葡萄糖酸盐以前曾被报道，以改善内皮功能，在自发性高血压大鼠，可能是因为在内皮细胞中的NO可用性增加，由于氧化应激的衰减;在我们的研究中，我们试图看看这是否也将是在人类患有原发性高血压的情况。对40名无糖尿病且胆固醇水平正常的高血压患者进行了检查。参与者随机摄入10 g干西兰花芽，一种具有高体外抗氧化潜力的硫代葡萄糖苷天然供体，为期4周，或继续他们的普通饮食并作为对照。每隔一周采集受试者的血压、血流介导的血管舒张功能（FMD）和血液样本，并在研究前和研究后测定硫代葡萄糖酸苷的含量。测量对治疗分配设盲。在干预组中，总体FMD从4%增加到干预组的5.8%，而在对照组中，FMD稳定（基线时为4%，研究结束时为3.9%）。干预组中FMD的变化主要是由于两名参与者的FMD发生了显著变化，而其他参与者的FMD没有发生显著变化。观察到的差异无统计学显著性。同样，在组间或组内未检测到血压或血液样本的显著变化。两组的舒张压基本保持不变，而介入组的收缩压从开始时的153 mm Hg小幅降低（9 mm Hg）。每日摄入10克干西兰花芽不会改善高血压患者的内皮功能。Clinicaltrials.gov NCT00252018
Ingestion of glucosinolates has previously been reported to improve endothelial function in spontaneously hypertensive rats, possibly because of an increase in NO availability in the endothelium due to an attenuation of oxidative stress; in our study we tried to see if this also would be the case in humans suffering from essential hypertension. 40 hypertensive individuals without diabetes and with normal levels of cholesterol were examined. The participants were randomized either to ingest 10 g dried broccoli sprouts, a natural donor of glucosinolates with high in vitro antioxidative potential, for a 4 week period or to continue their ordinary diet and act as controls. Blood pressure, endothelial function measured by flow mediated dilation (FMD) and blood samples were obtained from the participants every other week and the content of glucosinolates was measured before and after the study. Measurements were blinded to treatment allocation. In the interventional group overall FMD increased from 4% to 5.8% in the interventional group whereas in the control group FMD was stable (4% at baseline and 3.9% at the end of the study). The change in FMD in the interventional group was mainly due to a marked change in FMD in two participants while the other participants did not have marked changes in FMD. The observed differences were not statistically significant. Likewise significant changes in blood pressure or blood samples were not detected between or within groups. Diastolic blood pressure stayed essentially unchanged in both groups, while the systolic blood pressure showed a small non significant decrease (9 mm Hg) in the interventional group from a value of 153 mm Hg at start. Daily ingestion of 10 g dried broccoli sprouts does not improve endothelial function in the presence of hypertension in humans. Clinicaltrials.gov NCT00252018
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