The importance of dQ/dt on the flow field in a turbodynamic pump with pulsatile flow.
The importance of dQ/dt on the flow field in a turbodynamic pump with pulsatile flow.
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dQ/dt 对脉动流涡轮动力泵流场的重要性。
DOI：
10.1111/j.1525-1594.2009.00849.x
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发表时间：
2009
影响因子：
2.4
通讯作者：
Antaki,JamesF
中科院分区：
文献类型：
--
作者：
Shu,Fangjun;Vandenberghe,Stijn;Antaki,JamesF
涡轮血泵的流体动力学分析通常是在定常流动条件下进行的。然而，心室辅助的临床应用的优势涉及不稳定的脉动流-由于天然心脏的残余收缩性。本研究旨在证明脉动性和相关流速时间导数（dQ/dt）对临床规模TBP内血流动力学的重要性。这是通过对置于心血管模拟器内的离心TBP的透明模型进行流动可视化研究来实现的，该模型具有可控的心率和每搏输出量。采用粒子图像测速技术，对叶轮旋转角度和心动周期相位进行触发，对16个心动周期相位的出口蜗壳和叶轮叶片之间的速度场进行定量分析。在相同的（瞬时）流速下，非定常流场与相应的定常条件的比较显示出明显的差异。特别是，发现流的减速促进出口扩散器内的分离，而加速用于稳定速度场。加速和减速阶段之间的显著差异说明了惯性流体力的重要性。这些研究强调了dQ/dt作为独立变量对拟用作心室辅助器械的TBP进行全面临床前验证的重要性。
Fluid dynamic analysis of turbodynamic blood pumps (TBPs) is often conducted under steady flow conditions. However, the preponderance of clinical applications for ventricular assistance involves unsteady, pulsatile flow—due to the residual contractility of the native heart. This study was undertaken to demonstrate the importance of pulsatility and the associated time derivative of the flow rate (dQ/dt) on hemodynamics within a clinical‐scale TBP. This was accomplished by performing flow visualization studies on a transparent model of a centrifugal TBP interposed within a cardiovascular simulator with controllable heart rate and stroke volume. Particle image velocimetry triggered to both the rotation angle of the impeller and phase of the cardiac cycle was used to quantify the velocity field in the outlet volute and in between the impeller blades for 16 phases of the cardiac cycle. Comparison of the unsteady flow fields to corresponding steady conditions at the same (instantaneous) flow rates revealed marked differences. In particular, deceleration of flow was found to promote separation within the outlet diffuser, while acceleration served to stabilize the velocity field. The notable differences between the acceleration and deceleration phases illustrated the prominence of inertial fluid forces. These studies emphasize the importance of dQ/dt as an independent variable for thorough preclinical validation of TBPs intended for use as a ventricular assist device.
在存在流动的情况下红细胞粘附到异物表面。
DOI：
--
发表时间：
1974
期刊：
Journal of Biomedical Materials Research
影响因子：
--
作者：
N. Mohandas;R. Hochmuth;E. E. Spaeth
通讯作者：
E. E. Spaeth
DOI：
--
发表时间：
2001
期刊：
影响因子：
--
作者：
Zhongjun J. Wu;R. Gottlieb;G. Burgreen;John A. Holmes;D. Borzelleca;M. Kameneva;Griffith Bp;J. Antaki
通讯作者：
J. Antaki