Relationship between photoreceptor layer changes before half-dose photodynamic therapy and functional and anatomic outcomes in central serous chorioretinopathy
Relationship between photoreceptor layer changes before half-dose photodynamic therapy and functional and anatomic outcomes in central serous chorioretinopathy
复制标题
半剂量光动力治疗前感光层变化与中心性浆液性脉络膜视网膜病变的功能和解剖结果之间的关系
DOI：
10.1038/s41433-020-1018-6
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Jiang Chunhui
中科院分区：
文献类型：
--
作者：
Yu Jia;Ye Xiaofeng;Li Lei;Chang Qing;Jiang Chunhui
目的探讨中心性浆液性脉络膜视网膜病变(CSC)患者半剂量光动力疗法(PDT)前光感受器层(PRL)改变与功能和解剖结局的关系。方法采用光学相干断层扫描对PRL改变进行分类：(1)无黄斑中心凹PRL缺损区的光滑PRL外缘；(2)伴有黄斑中心凹PRL缺损区的光滑PRL外缘；(3)颗粒状PRL外缘；(4)散在斑点状PRL。比较半量PDT治疗12个月后的最佳矫正视力(BCVA)、黄斑中心凹外核层厚度(ONL)与对侧眼的差异以及椭圆形带(EZ)的完整性。第4组术后1年裸眼视力较差(20/2000~20/400)，无明显改善(P= 0.088)。在其他组中，平均最佳矫正视力显著改善至20/25或更好(均P<； 0.001)。第1组黄斑中心凹ONL厚度减少最小(−5.12 ± 6.89 μm)，EZ完整(33/33)；而第4组黄斑中心凹ONL厚度减少最大(−70.00 ± 7.87 μm)，EZ破裂(4/4)。第2组和第3组表现相似：黄斑前部视网膜中央膜层厚度均明显减少(−分别为19.21 ± 18.53和−20.75 ± 17.62 μm)，但EZ通常为连续的(分别为18/19和69/76)。这一信息可以帮助临床医生更好地确定CSC中半剂量PDT的治疗时机。
ObjectivesTo investigate the relationship between photoreceptor layer (PRL) changes before half-dose photodynamic therapy (PDT) and functional and anatomic outcomes in central serous chorioretinopathy (CSC).MethodsBaseline PRL changes were classified based on optical coherence tomography: (1) smooth PRL outer border without a foveal PRL defect; (2) smooth PRL outer border with a foveal PRL defect; (3) granulated PRL outer border and (4) scattered dots of PRL. The best-corrected visual acuity (BCVA), difference in the foveal outer nuclear layer (ONL) thickness between the CSC and normal contralateral eyes and ellipsoid zone (EZ) integrity 12 months after half-dose PDT were compared.ResultsIn total, 132 patients were included. Group 4 eyes had rather poor BCVA (20/2000–20/400) with little improvement (P= 0.088) at 1 year following half-dose PDT. In the other groups, the mean BCVA improved significantly to 20/25 or better (allP< 0.001). Group 1 eyes had the smallest foveal ONL thickness reduction (−5.12 ± 6.89 μm) and intact EZs (33/33), whereas Group 4 eyes had the largest foveal ONL thickness reduction (−70.00 ± 7.87 μm) and disrupted EZs (4/4). Group 2 and Group 3 eyes behaved similarly: they both had notable foveal ONL thickness reductions (−19.21 ± 18.53 and −20.75 ± 17.62 μm, respectively), but usually continuous EZs (18/19 and 69/76, respectively).ConclusionsThe PRL change category before half-dose PDT was closely related to functional and anatomic outcomes. This information could aid clinicians to better determine the timing of treatment with half-dose PDT in CSC.
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DOI：
10.1016/b978-0-323-02598-0.50069-0
发表时间：
2006
期刊：
--
影响因子：
--
作者：
C. Klais;Michael D. Ober;A. Ciardella;L. Yannuzzi
通讯作者：
C. Klais;Michael D. Ober;A. Ciardella;L. Yannuzzi
影响因子：
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作者：
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Yannuzzi, Lawrence A.
DOI：
10.35248/2593-8509.16.1.i101
发表时间：
2016-11
期刊：
--
影响因子：
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作者：
Yassine Mouzari;Mohammed Kriet
通讯作者：
Yassine Mouzari;Mohammed Kriet
DOI：
10.1097/iae.0b013e31826710a0
发表时间：
2013-02-01
影响因子：
3.3
作者：
Hata, Masayuki;Oishi, Akio;Kurimoto, Yasuo
通讯作者：
Kurimoto, Yasuo
影响因子：
4.2
作者：
Chang, Yo-Chen;Lin, Wei-Ning;Wu, Wen-Chuan
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Wu, Wen-Chuan