Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients.
Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients.
复制标题
干扰素诱导趋化因子转录水平升高与系统性红斑狼疮患者疾病活动和器官损伤的关联。
DOI：
10.1186/ar2510
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发表时间：
2008
影响因子：
4.9
通讯作者：
Bao, Chunde
中科院分区：
文献类型：
--
作者：
Fu, Qiong;Chen, Xiaoqing;Cui, Huijuan;Guo, Yanzhi;Chen, Jing;Shen, Nan;Bao, Chunde
系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病，具有异质性的过程和不同程度的严重程度和器官损害，因此，有越来越多的兴趣，确定SLE的生物标志物。在这项研究中，我们将多种干扰素诱导的趋化因子的联合表达水平与SLE的疾病活动性、器官损害程度和临床特征相关联，并研究它们作为生物标志物的作用。从67名SLE患者、20名类风湿性关节炎（RA）患者和23名健康供体获得的外周血细胞进行实时PCR，以测量七种干扰素诱导的趋化因子（RANTES、MCP-1、CCL 19、IL 19、IP-10、CXCL 11和IL-8）的转录水平。这些数据被用来计算每个参与者的趋化因子评分，然后在不同的SLE患者组和对照组之间进行比较。SLE患者的趋化因子评分显著高于RA患者和健康供体（分别为P = 0.012和P = 0.002）。趋化因子评分与SLE疾病活动指数2000评分呈正相关（P = 0.005），与C3水平呈负相关（P < 0.001）。与非狼疮性肾炎和活动期狼疮性肾炎患者相比，活动期狼疮性肾炎患者的趋化因子评分升高，尤其是当泼尼松日剂量低于30 mg时（分别为P = 0.002和P = 0.014）。趋化因子评分升高还与累积器官损伤（系统性狼疮国际合作临床/美国流变学学会损伤指数≥ 1; P = 0.010）和抗Sm或抗RNP自身抗体的发生相关（均P = 0.021）。外周血白细胞中干扰素诱导趋化因子的联合转录水平与SLE的疾病活动性、器官损害程度和特异性自身抗体模式密切相关。趋化因子评分可作为SLE活动性和严重程度的新的生物标志物。
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with a heterogeneous course and varying degrees of severity and organ damage; thus, there is increasing interest in identifying biomarkers for SLE. In this study we correlated the combined expression level of multiple interferon-inducible chemokines with disease activity, degree of organ damage and clinical features in SLE, and we investigated their roles as biomarkers. Peripheral blood cells obtained from 67 patients with SLE patients, 20 patients with rheumatoid arthritis (RA) and 23 healthy donors were subjected to real-time PCR in order to measure the transcriptional levels of seven interferon-inducible chemokines (RANTES, MCP-1, CCL19, MIG, IP-10, CXCL11, and IL-8). The data were used to calculate a chemokine score for each participant, after which comparisons were performed between various groups of SLE patients and control individuals. Chemokine scores were significantly elevated in SLE patients versus RA patients and healthy donors (P = 0.012 and P = 0.002, respectively). Chemokine scores were correlated positively with SLE Disease Activity Index 2000 scores (P = 0.005) and negatively with C3 levels (P < 0.001). Compared with patients without lupus nephritis and those with inactive lupus nephritis, chemokine scores were elevated in patients with active lupus nephritis, especially when their daily prednisone dosage was under 30 mg (P = 0.002 and P = 0.014, respectively). Elevated chemokine scores were also associated with the presence of cumulative organ damage (Systemic Lupus International Collaborating Clinics/American Society of Rheumatology Damage Index ≥ 1; P = 0.010) and the occurrence of anti-Sm or anti-RNP autoantibodies (both P = 0.021). The combined transcription level of interferon-inducible chemokines in peripheral blood leucocytes is closely associated with disease activity, degree of organ damage, and specific autoantibody patterns in SLE. The chemokine score may serve as a new biomarker for active and severe disease in SLE.
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DOI：
10.1084/jem.184.3.963
发表时间：
1996-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Loetscher M;Gerber B;Loetscher P;Jones SA;Piali L;Clark-Lewis I;Baggiolini M;Moser B
通讯作者：
Moser B
DOI：
10.1084/jem.20021553
发表时间：
2003-03-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bennett L;Palucka AK;Arce E;Cantrell V;Borvak J;Banchereau J;Pascual V
通讯作者：
Pascual V
影响因子：
--
作者：
de Padilla, Consuelo M. Lopez;Vallejo, Abbe N.;Reed, Ann M.
通讯作者：
Reed, Ann M.
影响因子：
--
作者：
Hasegawa, H;Kohno, M;Fujita, S
通讯作者：
Fujita, S
影响因子：
--
作者：
Kirou, KA;Lee, C;Crow, MK
通讯作者：
Crow, MK