BOLD Granger causality reflects vascular anatomy.
BOLD Granger causality reflects vascular anatomy.
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DOI：
10.1371/journal.pone.0084279
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Anderson JS
中科院分区：
文献类型：
--
作者：
Webb JT;Ferguson MA;Nielsen JA;Anderson JS
许多研究试图利用BOLD时间序列中的细微相位差来解析大脑区域的顺序激活，或者更一般地说，一个区域中的信号预测另一个区域中后续信号的能力。最近，这种基于滞后的措施已被应用于调查定向功能连接，虽然这个应用程序一直有争议。我们试图使用大型公开数据集（FCON 1000，ADHD 200，人类连接组计划），以确定是否一致的空间模式的格兰杰因果关系观察到典型的功能磁共振成像数据。对于来自1，240名年龄在7-40岁之间的典型发育受试者的BOLD数据集，我们测量了每对7，266个覆盖灰质的球形ROI和264个位于大脑功能网络架构中心的种子ROI的时间序列之间的格兰杰因果关系。格兰杰因果关系估计是强重现的连接在一个测试和复制样本（n=620名受试者为每组），以及从一个单一的主题重复扫描的数据，无论是在休息和被动的视频观看。同样的效果是更强的高时间分辨率的功能磁共振成像数据从人类连接组计划，并独立观察到在7个任务范式的性能过程中收集的数据。格兰杰因果关系的空间分布反映了血管解剖学，从格兰杰因果关系源（Willis环动脉流入分布）到汇（靠近大静脉血管结构，如硬脑膜静脉窦和大脑外周）的进展。尝试用格兰杰因果关系解决BOLD相位差时，应考虑可重现血管混淆的可能性，这是一个与血流动力学反应的已知区域变异性无关的问题。
A number of studies have tried to exploit subtle phase differences in BOLD time series to resolve the order of sequential activation of brain regions, or more generally the ability of signal in one region to predict subsequent signal in another region. More recently, such lag-based measures have been applied to investigate directed functional connectivity, although this application has been controversial. We attempted to use large publicly available datasets (FCON 1000, ADHD 200, Human Connectome Project) to determine whether consistent spatial patterns of Granger Causality are observed in typical fMRI data. For BOLD datasets from 1,240 typically developing subjects ages 7–40, we measured Granger causality between time series for every pair of 7,266 spherical ROIs covering the gray matter and 264 seed ROIs at hubs of the brain’s functional network architecture. Granger causality estimates were strongly reproducible for connections in a test and replication sample (n=620 subjects for each group), as well as in data from a single subject scanned repeatedly, both during resting and passive video viewing. The same effect was even stronger in high temporal resolution fMRI data from the Human Connectome Project, and was observed independently in data collected during performance of 7 task paradigms. The spatial distribution of Granger causality reflected vascular anatomy with a progression from Granger causality sources, in Circle of Willis arterial inflow distributions, to sinks, near large venous vascular structures such as dural venous sinuses and at the periphery of the brain. Attempts to resolve BOLD phase differences with Granger causality should consider the possibility of reproducible vascular confounds, a problem that is independent of the known regional variability of the hemodynamic response.
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HD-200 Consortium
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HD-200 Consortium
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3.4
作者：
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通讯作者：
Yurgelun-Todd D