Anxious depression in elderly patients. Response to antidepressant treatment.
Anxious depression in elderly patients. Response to antidepressant treatment.
复制标题
老年患者焦虑抑郁。
DOI：
--
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
S. Rifat
中科院分区：
文献类型：
--
作者：
A. Flint;S. Rifat
作者询问是否患有焦虑抑郁症的老年患者对抗抑郁药治疗的反应比非焦虑抑郁症患者低。一组101名抑郁症患者接受了6周的去甲替林治疗，如果必要的话，再接受2周的碳酸锂治疗。对一线治疗没有反应或不耐受的患者随后接受6周的苯乙肼（+/-锂加强）。最后，二线治疗失败的患者接受一个疗程的电休克治疗或6周的氟西汀（+/-锂增强）。根据他们在医院焦虑和抑郁量表上的评分，将受试者分为焦虑组和非焦虑组。在意向治疗和疗效分析中，焦虑性抑郁症患者对去甲替林的反应明显较低。他们也更有可能停止治疗，因此，在意向治疗分析中对总体治疗的反应明显较低。这些结果表明，并发的焦虑症状在老年抑郁症的预后重要性。
The authors asked whether elderly patients with anxious depression were less responsive to antidepressant treatment than nonanxious depressed patients. A group of 101 depressed patients were treated with 6 weeks of nortriptyline and then, if necessary, 2 weeks of adjunctive lithium. Patients who did not respond to or were intolerant of this first line of treatment were then given 6 weeks of phenelzine (+/- lithium augmentation). Finally, patients failing this second line of treatment were given either a course of electroconvulsive therapy or 6 weeks of fluoxetine (+/- lithium augmentation). Based on their score on the Hospital Anxiety and Depression Scale at index assessment, subjects were divided into anxious and nonanxious groups. Anxious depressed patients were significantly less responsive to nortriptyline on both intent-to-treat and efficacy analyses. They were also more likely to discontinue treatment and, as a result, were significantly less responsive on the intent-to-treat analysis for overall treatment. These results suggest that concurrent symptoms of anxiety have prognostic importance in geriatric depression.
DOI：
--
发表时间：
1992
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
M. Thase;Ellen Frank;A. Mallinger;T. Hamer;Dj Kupfer
通讯作者：
M. Thase;Ellen Frank;A. Mallinger;T. Hamer;Dj Kupfer
抑郁症和恐慌症：随访和家庭研究数据所反映的重叠的重要性。
DOI：
10.1176/ajp.145.3.293
发表时间：
1988
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Coryell,W;Endicott,J;Andreasen,NC;Keller,MB;Clayton,PJ;Hirschfeld,RM;Scheftner,WA;Winokur,G
通讯作者：
Winokur,G